Detailed flow cytometric analysis of platelets in blood of mice during the course of P berghei malaria
. | . | . | . | P . | . | |
---|---|---|---|---|---|---|
. | Day 0 . | Day 4 . | Day 6 . | Day 0 vs day 4 . | Day 0 vs day 6 . | |
% CD41+ cells forming intact RBC conjugates | 8.6 ± 2.5 | 10.0 ± 2.4 | 36.0 ± 5.0 | .7 | < .0001 | |
% CD41+ cells forming microparticles | 8.8 ± 1.0 | 6.2 ± 0.9 | 3.2 ± 0.9 | < .0001 | < .0001 | |
% CD41+ cells in platelet region | 81 ± 2 | 82 ± 2 | 57 ± 5 | .9 | < .0001 | |
% microparticles that are CD41+ | 31.2 ± 14.2 | 18.1 ± 10.2 | 0.4 ± 0.2 | .1 | .0002 | |
% microparticles that are Ter119+ | 55.0 ± 16.8 | 56.2 ± 7.4 | 89.1 ± 1.8 | .99 | .0003 | |
No. CD41+ cells | 848 136 ± 475 698 | 264 841 ± 173 789 | 20 191 ± 3 593 | .03 | .002 | |
No. CD41+ microparticles | 72 953 ± 39 499 | 16 472 ± 11 438 | 617 ± 82 | .009 | .0009 | |
No. CD41+ cells in platelet region | 683 532 ± 372 774 | 219 228 ± 145 295 | 11 645 ± 3 231 | .02 | .001 | |
No. CD41+ platelet: intact RBC conjugates | 79 851 ± 62 859 | 24 643 ± 16 642 | 7 157 ± 689 | .1 | .04 |
. | . | . | . | P . | . | |
---|---|---|---|---|---|---|
. | Day 0 . | Day 4 . | Day 6 . | Day 0 vs day 4 . | Day 0 vs day 6 . | |
% CD41+ cells forming intact RBC conjugates | 8.6 ± 2.5 | 10.0 ± 2.4 | 36.0 ± 5.0 | .7 | < .0001 | |
% CD41+ cells forming microparticles | 8.8 ± 1.0 | 6.2 ± 0.9 | 3.2 ± 0.9 | < .0001 | < .0001 | |
% CD41+ cells in platelet region | 81 ± 2 | 82 ± 2 | 57 ± 5 | .9 | < .0001 | |
% microparticles that are CD41+ | 31.2 ± 14.2 | 18.1 ± 10.2 | 0.4 ± 0.2 | .1 | .0002 | |
% microparticles that are Ter119+ | 55.0 ± 16.8 | 56.2 ± 7.4 | 89.1 ± 1.8 | .99 | .0003 | |
No. CD41+ cells | 848 136 ± 475 698 | 264 841 ± 173 789 | 20 191 ± 3 593 | .03 | .002 | |
No. CD41+ microparticles | 72 953 ± 39 499 | 16 472 ± 11 438 | 617 ± 82 | .009 | .0009 | |
No. CD41+ cells in platelet region | 683 532 ± 372 774 | 219 228 ± 145 295 | 11 645 ± 3 231 | .02 | .001 | |
No. CD41+ platelet: intact RBC conjugates | 79 851 ± 62 859 | 24 643 ± 16 642 | 7 157 ± 689 | .1 | .04 |
The percentages of CD41+ cells plus or minus SD forming platelet microparticles, intact platelets, and platelet-erythrocyte conjugates are provided, as is an analysis of microparticles and the number plus or minus SD of platelet microparticles, intact platelets, and platelet-erythrocyte conjugates. The day-0 values comprise all the uninfected animals (n = 20) and n = 5 for analysis on day 4 and day 6 of infection. RBC indicates red blood cell.