Loss of telomeric pairs per population doubling, HK1 cells
. | Telomere length . | . | No. population doublings . | . | . | |||
|---|---|---|---|---|---|---|---|---|
. | 7 d in culture . | 56 d in culture . | 7 d in culture . | 56 d in culture . | bp loss per PD . | |||
| Negative control | 8.8 | 6.9 | 3.9 | 32.7 | − 66.6 | |||
| DMSO | 8.4 | 6.8 | 3.5 | 31.5 | − 55.5 | |||
| BIBR1532 | ||||||||
| 10 μM | 9.0 | 6.7 | 3.2 | 31.7 | − 80.1 | |||
| 30 μM | 7.8 | 7.0 | 3.7 | 16.0 | − 68.7 | |||
| 50 μM | 8.3 | — | 3.3 | — | — | |||
. | Telomere length . | . | No. population doublings . | . | . | |||
|---|---|---|---|---|---|---|---|---|
. | 7 d in culture . | 56 d in culture . | 7 d in culture . | 56 d in culture . | bp loss per PD . | |||
| Negative control | 8.8 | 6.9 | 3.9 | 32.7 | − 66.6 | |||
| DMSO | 8.4 | 6.8 | 3.5 | 31.5 | − 55.5 | |||
| BIBR1532 | ||||||||
| 10 μM | 9.0 | 6.7 | 3.2 | 31.7 | − 80.1 | |||
| 30 μM | 7.8 | 7.0 | 3.7 | 16.0 | − 68.7 | |||
| 50 μM | 8.3 | — | 3.3 | — | — | |||
— indicates not done.