Analysis of the signal-free ends in JVM13 cells treated with HD-BIBR1532
. | SFE/Metaphase . | No. of Metaphases . |
|---|---|---|
| DMSO | 0 | 8 |
| BIBR 3 hrs | 0.33 | 9 |
| BIBR 6 hrs | 0.46 | 15 |
| BIBR 24 hrs | 0.70 | 10 |
. | SFE/Metaphase . | No. of Metaphases . |
|---|---|---|
| DMSO | 0 | 8 |
| BIBR 3 hrs | 0.33 | 9 |
| BIBR 6 hrs | 0.46 | 15 |
| BIBR 24 hrs | 0.70 | 10 |
Metaphase spreads were prepared from JVM13 cells treated with 80 μM BIBR1552 at different time points, namely 3, 6, and 24 hours. Missing telomere signals at both sister chromatids were counted as signal-free ends (SFE) and expressed as mean SFE per metaphase.