Summary of samples from patients with AML
Patient code . | TA . | TL . | CD34 % . | Blast % in BM . | FAB . | Karyotype . | Inhibition of proliferation, % . |
|---|---|---|---|---|---|---|---|
| 101 | + | 6.1 | + | 90 | M2 | ND | > 70 |
| 102 | + | ND | + | 75 | M4 | Normal | > 70 |
| 103 | + | 7.3 | − | 75 | M5 | Monosomy 12, 16, 17 | > 70 |
| 104 | − | 7.6 | − | 50 | ND | Normal | > 70 |
| 105 | − | ND | ND | 94 | M2 | Complex | > 70 |
| 106 | + | 6.3 | − | 85 | M4/2ryAML | Complex | < 50 |
| 107 | ND | ND | + | 80 | M4/M5 | Normal | > 70 |
| 108 | ND | ND | + | 80 | M2/MDS | Normal | > 70 |
| 109 | ND | ND | + | 75 | M5 | Normal | > 70 |
Patient code . | TA . | TL . | CD34 % . | Blast % in BM . | FAB . | Karyotype . | Inhibition of proliferation, % . |
|---|---|---|---|---|---|---|---|
| 101 | + | 6.1 | + | 90 | M2 | ND | > 70 |
| 102 | + | ND | + | 75 | M4 | Normal | > 70 |
| 103 | + | 7.3 | − | 75 | M5 | Monosomy 12, 16, 17 | > 70 |
| 104 | − | 7.6 | − | 50 | ND | Normal | > 70 |
| 105 | − | ND | ND | 94 | M2 | Complex | > 70 |
| 106 | + | 6.3 | − | 85 | M4/2ryAML | Complex | < 50 |
| 107 | ND | ND | + | 80 | M4/M5 | Normal | > 70 |
| 108 | ND | ND | + | 80 | M2/MDS | Normal | > 70 |
| 109 | ND | ND | + | 75 | M5 | Normal | > 70 |
Telomerase activity (TA) was determined using TRAP assay; telomere length (TL) was analyzed using flow-FISH. The response to 80 μM BIBR1532 is expressed as percentage of proliferation inhibition of the controls within 72 hours of culture.
FAB indicates French-American-British; +, positive; −, negative; ND, not detected.