Immunologic parameters
Variable . | All patients . | Less than 23% HLA-G—positive cells . | 23% or more HLA-G—positive cells . | P* . |
|---|---|---|---|---|
| Immunglobulin G, g/L, n = 43 | 7.08 ± 3.03† | 7.51 ± 2.9† | 5.47 ± 3.1† | .042 |
| Immunglobulin A, g/L n = 43 | 0.88 ± 0.7† | 0.91 ± 0.7† | 0.77 ± 0.9† | NS |
| Immunglobulin M, g/L, n = 43 | 0.54 ± 0.6† | 0.54 ± 0.7† | 0.53 ± 0.6† | NS |
| Total T cells, per μL, n = 32 | 2780 ± 2475† | 3095 ± 2567† | 1076 ± 581† | .005 |
| CD4+ T cells, per μL, n = 32 | 1508 ± 1304† | 1685 ± 1344† | 556 ± 291† | .016 |
| CD8+ T cells, per μL, n = 32 | 1172 ± 1249† | 1299 ± 1317† | 586 ± 351† | .077 |
| CD4/CD8 ratio, n = 32 | 1.85 ± 1.6† | 1.93 ± 1.7† | 1.4 ± 0.7† | NS |
| IL-10, pg/mL, n = 47 | 5.1 (6.1-43.1)‡ | 4.9 (6.1-43.1)‡ | 10.2 (9.9-40.2)‡ | NS |
| sHLA-G, pg/mL, n = 47 | 17.3 (0.0-82.8)‡ | 16.7 (0.0-82.8)‡ | 26.9 (0.0-34.8)‡ | .043 |
Variable . | All patients . | Less than 23% HLA-G—positive cells . | 23% or more HLA-G—positive cells . | P* . |
|---|---|---|---|---|
| Immunglobulin G, g/L, n = 43 | 7.08 ± 3.03† | 7.51 ± 2.9† | 5.47 ± 3.1† | .042 |
| Immunglobulin A, g/L n = 43 | 0.88 ± 0.7† | 0.91 ± 0.7† | 0.77 ± 0.9† | NS |
| Immunglobulin M, g/L, n = 43 | 0.54 ± 0.6† | 0.54 ± 0.7† | 0.53 ± 0.6† | NS |
| Total T cells, per μL, n = 32 | 2780 ± 2475† | 3095 ± 2567† | 1076 ± 581† | .005 |
| CD4+ T cells, per μL, n = 32 | 1508 ± 1304† | 1685 ± 1344† | 556 ± 291† | .016 |
| CD8+ T cells, per μL, n = 32 | 1172 ± 1249† | 1299 ± 1317† | 586 ± 351† | .077 |
| CD4/CD8 ratio, n = 32 | 1.85 ± 1.6† | 1.93 ± 1.7† | 1.4 ± 0.7† | NS |
| IL-10, pg/mL, n = 47 | 5.1 (6.1-43.1)‡ | 4.9 (6.1-43.1)‡ | 10.2 (9.9-40.2)‡ | NS |
| sHLA-G, pg/mL, n = 47 | 17.3 (0.0-82.8)‡ | 16.7 (0.0-82.8)‡ | 26.9 (0.0-34.8)‡ | .043 |
NS indicates not significant.
In most patients, the laboratory parameters were not determined at diagnosis, but during the course of the disease. Normal ranges are as follows: IgG, 7 to 26 g/L; IgA, 0.7 to 4.0 g/L; IgM, 0.3 to 2 g/L; total T cells, 690 to 2540/μL; CD4+ T cells, 410 to 1590/μL; CD8+ T cells, 190 to 1140/μL; CD4/CD8 ratio, 1.0 to 3.0; IL-10, 20.1 ± 33.2 pg/mL; and sHLA-G, 22.9 ± 16.9 ng/mL.
Comparison between the HLA-G-positive and HLA-G-negative subgroups using the Mann-Whitney U test.
Mean ± standard error of the mean.
Median (range).