Table 1. Spectrum of etoposide-induced... | American Society of Hematology

Table 1.

Spectrum of etoposide-induced MLL locus repair products in primary CD34⁺ cells

	Short recovery	Long recovery
*Internal MLL* rearrangements**
Tandem duplication^*	15	26
Deletion	1	1
Inversion	0	4
Fusion to novel sequence
Insertion	3	1
Translocation^*	15†	1
Total clones analyzed	34	33

	Short recovery	Long recovery
*Internal MLL* rearrangements**
Tandem duplication^*	15	26
Deletion	1	1
Inversion	0	4
Fusion to novel sequence
Insertion	3	1
Translocation^*	15†	1
Total clones analyzed	34	33

P values calculated by the Fisher 2-tailed exact test. The increase in relative frequency of tandem duplications (P < .006) is paralleled by the significant decrease in translocations (P < .00002)

†

Of these events, 3 were complex with insertions of novel sequence at the translocation junctions

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