HOXB6 increases CRU frequency
Vector . | CRU frequency . | 95% CI . | Fold expansion . |
|---|---|---|---|
| MIG | 1 in 6.3 × 106 | 1 in 3.1-13 × 106 | — |
| HOXB6 | 1 in 4.0 × 104 | 1 in 3.0-5.3 × 104 | 160 |
| HOXB6WG | 1 in 2.1 × 105 | 1 in 1.4-3.1 × 105 | 30 |
| MIGB6NA | 1 in 5.1 × 105 | 1 in 3.7-7.0 × 105 | 12 |
Vector . | CRU frequency . | 95% CI . | Fold expansion . |
|---|---|---|---|
| MIG | 1 in 6.3 × 106 | 1 in 3.1-13 × 106 | — |
| HOXB6 | 1 in 4.0 × 104 | 1 in 3.0-5.3 × 104 | 160 |
| HOXB6WG | 1 in 2.1 × 105 | 1 in 1.4-3.1 × 105 | 30 |
| MIGB6NA | 1 in 5.1 × 105 | 1 in 3.7-7.0 × 105 | 12 |
For each vector, 2 primary transplant chimeras were killed for CRU donors (except MIG, n = 4) and 3 to 4 dilutions analyzed per experiment (secondary recipient n = 32, 36, 22, and 29 for MIG, HOXB6, HOXB6WG, and HOXB6NA, respectively). Fold expansion is expressed relative to MIG control.
— indicates that MIG is the control to which other vectors are compared.