Table 2. Comparison of anti-CD3 effects... | American Society of Hematology

Table 2.

Comparison of anti-CD3 effects on thymocytes in Tcl1^-/--deficient versus -nondeficient mice

	Tcl1^+/+ and Tcl1^+/-					Tcl1^-/-
	Mean cell no. × 10⁵, ± SE				Mean cell no. × 10⁵, ± SE
Thymocyte population	Control	Anti-CD3^*	Fold decrease	Control	Anti-CD3	Fold decrease
CD4^-CD8^-	33.4 ± 2.8†	9.0 ± 1.7	3.6	24.1 ± 2.1	15.9 ± 3.6	1.5
CD4⁺CD8⁺	1019 ± 65.1	64.4 ± 15.5	15.8	679 ± 104.1	12.1 ± 7.4	56.5
CD4⁺CD8^-	61.1 ± 6.0	29.4 ± 2.5	2.1	50.7 ± 6.5	9.6 ± 2.4	5.3
CD4^-CD8⁺	26.3 ± 2.5	12.6 ± 1.0	2.1	23.7 ± 3.1	5.9 ± 1.4	4.0
Total	1115 ± 80.4	115.4 ± 19.5	9.6	801 ± 101	43.5 ± 11.5	18.4

	Tcl1^+/+ and Tcl1^+/-					Tcl1^-/-
	Mean cell no. × 10⁵, ± SE				Mean cell no. × 10⁵, ± SE
Thymocyte population	Control	Anti-CD3^*	Fold decrease	Control	Anti-CD3	Fold decrease
CD4^-CD8^-	33.4 ± 2.8†	9.0 ± 1.7	3.6	24.1 ± 2.1	15.9 ± 3.6	1.5
CD4⁺CD8⁺	1019 ± 65.1	64.4 ± 15.5	15.8	679 ± 104.1	12.1 ± 7.4	56.5
CD4⁺CD8^-	61.1 ± 6.0	29.4 ± 2.5	2.1	50.7 ± 6.5	9.6 ± 2.4	5.3
CD4^-CD8⁺	26.3 ± 2.5	12.6 ± 1.0	2.1	23.7 ± 3.1	5.9 ± 1.4	4.0
Total	1115 ± 80.4	115.4 ± 19.5	9.6	801 ± 101	43.5 ± 11.5	18.4

Treated animals received 25 mg anti-CD3ϵ antibody intraperitoneally 2 days before analysis

Results for 6 mice, 8 to 12 weeks old, in each group