Predictors of response to Cbl therapy
Parameter . | Total no. . | Responders, no. (%) . | Nonresponders, no. (%) . |
|---|---|---|---|
| No. treated | 62 | 37 (60) | 25 (40) |
| Low serum Cbl | |||
| Less than 201 pg/mL | 11 | 6 (55) | 5 (45) |
| 201 pg/mL to 300 pg/mL | 20 | 11 (55) | 9 (45) |
| Greater than 300 pg/mL | 31 | 20 (65) | 11 (35) |
| High serum MMA | |||
| Greater than 376 nmol/L | 28 | 13 (46) | 15* (54) |
| 251 nmol/L to 376 nmol/L | 21 | 14† (67) | 7 (33) |
| Less than 251 nmol/L | 11 | 8‡ (73) | 3 (27) |
| High serum HCys | |||
| Greater than 13.6 μmol/L | 24 | 15†§ (63) | 9 (37) |
| 12.2 μmol/L to 13.6 μmol/L | 6 | 2 (33) | 4 (67) |
| Less than 12.2 μmol/L | 25 | 17 (50) | 8 (32) |
Parameter . | Total no. . | Responders, no. (%) . | Nonresponders, no. (%) . |
|---|---|---|---|
| No. treated | 62 | 37 (60) | 25 (40) |
| Low serum Cbl | |||
| Less than 201 pg/mL | 11 | 6 (55) | 5 (45) |
| 201 pg/mL to 300 pg/mL | 20 | 11 (55) | 9 (45) |
| Greater than 300 pg/mL | 31 | 20 (65) | 11 (35) |
| High serum MMA | |||
| Greater than 376 nmol/L | 28 | 13 (46) | 15* (54) |
| 251 nmol/L to 376 nmol/L | 21 | 14† (67) | 7 (33) |
| Less than 251 nmol/L | 11 | 8‡ (73) | 3 (27) |
| High serum HCys | |||
| Greater than 13.6 μmol/L | 24 | 15†§ (63) | 9 (37) |
| 12.2 μmol/L to 13.6 μmol/L | 6 | 2 (33) | 4 (67) |
| Less than 12.2 μmol/L | 25 | 17 (50) | 8 (32) |
MMA was not measured before therapy in 2 responders while HCys was not measured before therapy in 3 responders and 4 nonresponders. Serum or red cell folate levels were normal in the 9 patients with Cbl levels less than 201 pg/mL tested and in all 30 patients with HCys values greater than 12.1 μmol/L.
One patient with normal renal function did not have a fall in MMA after Cbl therapy.
One patient with mild renal failure did not have a fall in either MMA or HCys after Cbl therapy.
Includes 2 patients with pretherapy MMA reported as less than 400 nmol/L.
One patient with excessive alcohol consumption did not have a fall in HCys after Cbl therapy.