Binding kinetics and affinity of anti–human CTLA-4 mAb to huCTLA-4Ig fusion protein
Antibody clone . | Average ka ± SD, 1/ms, 105 . | Average kd ± SD, 1/s, 10-4 . | KD ± SD, nM, 10-9 . |
|---|---|---|---|
| L3D10 | 2.07 ± 0.25 | 6.33 ± 3.18 | 3.06 ± 1.70 |
| L1B11 | 1.10 ± 0.11 | 12.00 ± 1.32 | 10.9 ± 1.75 |
| K4G4 | 1.99 ± 0.27 | 6.82 ± 2.20 | 3.40 ± 1.40 |
| KM10 | 2.11 ± 0.21 | 1.72 ± 0.34 | 0.82 ± 0.23 |
| YL2 | 3.61 ± 0.28 | 2.61 ± 0.52 | 0.72 ± 0.20 |
Antibody clone . | Average ka ± SD, 1/ms, 105 . | Average kd ± SD, 1/s, 10-4 . | KD ± SD, nM, 10-9 . |
|---|---|---|---|
| L3D10 | 2.07 ± 0.25 | 6.33 ± 3.18 | 3.06 ± 1.70 |
| L1B11 | 1.10 ± 0.11 | 12.00 ± 1.32 | 10.9 ± 1.75 |
| K4G4 | 1.99 ± 0.27 | 6.82 ± 2.20 | 3.40 ± 1.40 |
| KM10 | 2.11 ± 0.21 | 1.72 ± 0.34 | 0.82 ± 0.23 |
| YL2 | 3.61 ± 0.28 | 2.61 ± 0.52 | 0.72 ± 0.20 |
Binding kinetics were determined by Biacore.