Assessment of survival following BMT with alterations in the fraction of IL-15 tg B6 donor BM cells transplanted into B6D2F1 recipients
Recipient . | Percent IL-15 tg B6 BM cells . | Median survival time, d . | P, log-rank test . |
|---|---|---|---|
| B6D2F1 | 100 | 14.5 | NA |
| B6D2F1 | 50 | 14 | NS |
| B6D2F1 | 25 | 22 | .004 |
| B6D2F1 | 0 | 30 | .01 |
Recipient . | Percent IL-15 tg B6 BM cells . | Median survival time, d . | P, log-rank test . |
|---|---|---|---|
| B6D2F1 | 100 | 14.5 | NA |
| B6D2F1 | 50 | 14 | NS |
| B6D2F1 | 25 | 22 | .004 |
| B6D2F1 | 0 | 30 | .01 |
For all recipients, the total number of wt B6 splenic T cells was 5 × 106, and the total number of BM cells was 1 × 107. Median survival times for mice that received transplants of a given percentage of IL-15 tg BM cells were compared with the MSTs for mice that received transplants with an immediately higher percentage of IL-15 tg BM cells, as shown in the table. NA indicates not applicable; NS, not significant.