Selected genes repressed by both hypoxia and AdCA5
Unigene . | Gene name . | Symbol . | Hypoxia . | AdCA5 . |
---|---|---|---|---|
CDC/cyclins | ||||
Hs.408658 | Cyclin E2 | CCNE2 | - 1.7 | - 4.1 |
Hs.244723 | Cyclin E1 | CCNE1 | - 1.9 | - 3.9 |
Hs.1973 | Cyclin F | CCNF | - 2.1 | - 3.0 |
Hs.408658 | Cyclin E2 | CCNE2 | - 2.4 | - 2.8 |
Hs.334562 | Cell division cycle 2 | CDC2 | - 1.5 | - 2.2 |
Hs.405958 | Cell division cycle 6 | CDC6 | - 2.7 | - 2.1 |
Hs.334562 | Cell division cycle 2 | CDC2 | - 1.8 | - 2.1 |
Hs.28853 | Cell division cycle 7 | CDC7 | - 1.6 | - 2.1 |
Hs.334562 | Cell division cycle 2 | CDC2 | - 1.8 | - 1.9 |
MCM proteins | ||||
Hs.460184 | Minichromosome maintenance deficient 4 | MCM4 | - 2.4 | - 3.1 |
Hs.460184 | Minichromosome maintenance deficient 4 | MCM4 | - 2.2 | - 3.1 |
Hs.57101 | Minichromosome maintenance deficient 2 | MCM2 | - 2.2 | - 3.1 |
Hs.77171 | Minichromosome maintenance deficient 5 | MCM5 | - 2.4 | - 2.7 |
Hs.444118 | Minichromosome maintenance deficient 6 | MCM6 | - 1.9 | - 2.4 |
Hs.198363 | Minichromosome maintenance deficient 10 | MCM10 | - 2.2 | - 2.3 |
Hs.179565 | Minichromosome maintenance deficient 3 | MCM3 | - 1.5 | - 2.2 |
Hs.460184 | Minichromosome maintenance deficient 4 | MCM4 | - 1.8 | - 2.1 |
Hs.460184 | Minichromosome maintenance deficient 4 | MCM4 | - 2.0 | - 1.8 |
DNA/RNA polymerases | ||||
Hs.437186 | Polymerase (RNA) III polypeptide K | POLR3K | - 2.1 | - 4.3 |
Hs.441072 | Polymerase (RNA) II polypeptide L | RNAPOL2 | - 2.0 | - 3.3 |
Hs.99185 | Polymerase (DNA directed), epsilon 2 | POLE2 | - 2.0 | - 2.6 |
Hs.282387 | Polymerase (RNA) III (32kD) | RPC32 | - 1.9 | - 1.9 |
Hs.306791 | Polymerase (DNA directed), delta 2 | POLD2 | - 1.5 | - 1.7 |
Hs.290921 | Polymerase (DNA directed), gamma | POLG | - 1.7 | - 1.6 |
Replication factors | ||||
Hs.79018 | Chromatin assembly factor 1, subunit A | CHAF1A | - 6.0 | - 10.0 |
Hs.433180 | DNA replication complex GINS protein PSF2 | PFS2 | - 2.2 | - 3.4 |
Hs.194665 | DNA replication helicase 2-like | DNA2L | - 1.7 | - 3.3 |
Hs.443227 | Replication factor C5 | RFC5 | - 1.9 | - 3.2 |
Hs.115474 | Replication factor C (activator 1) 3 | RFC3 | - 1.9 | - 2.9 |
Hs.443227 | Replication factor C5 | RFC5 | - 1.6 | - 2.3 |
Hs.49760 | Origin recognition complex, subunit 6-like | ORC6L | - 1.9 | - 1.9 |
Hs.139226 | Replication factor C (activator 1) 2 | RFC2 | - 1.6 | - 1.6 |
Other cell cycle | ||||
Hs.23348 | S-phase kinase-associated protein 2 | SKP2 | - 2.4 | - 3.1 |
Hs.79078 | MAD2 mitotic arrest deficient-like 1 | MAD2L1 | - 1.7 | - 2.9 |
Hs.511945 | Block of proliferation 1 | BOP1 | - 1.7 | - 2.8 |
Hs.42650 | ZW10 interactor | ZWINT | - 2.0 | - 2.5 |
Hs.445084 | M-phase phosphoprotein 9 | MPHOSPH9 | - 1.7 | - 2.5 |
Hs.75337 | Nucleolar and coiled-body phosphoprotein 1 | NOLC1 | - 1.6 | - 2.4 |
Hs.374491 | Proliferation-associated 2G4 | PA2G4 | - 1.6 | - 2.1 |
Hs.152759 | Activator of S-phase kinase | ASK | - 2.7 | - 2.0 |
Hs.344037 | Protein regulator of cytokinesis 1 | PRC1 | - 2.0 | - 1.6 |
Hs.433008 | NIMA (never in mitosis a)-related kinase 4 | NEK4 | - 1.5 | - 1.5 |
Ribonucleotide metabolism | ||||
Hs.226390 | Ribonucleotide reductase M2 polypeptide | RRM2 | - 2.4 | - 7.2 |
Hs.464813 | Dihydrofolate reductase | DHFR | - 2.0 | - 4.5 |
Hs.251871 | CTP synthase | CTPS | - 1.8 | - 3.2 |
Hs.226390 | Ribonucleotide reductase M2 polypeptide | RRM2 | - 1.8 | - 2.4 |
Hs.56 | Phosphoribosyl pyrophosphate synthetase 1 | PRPS1 | - 1.6 | - 2.3 |
Hs.2057 | Uridine monophosphate synthetase | UMPS | - 1.6 | - 2.3 |
Hs.464813 | Dihydrofolate reductase | DHFR | - 1.5 | - 2.3 |
Hs.90280 | 5-aminoimidazole-4-carboxamide ribonucleotide transformylase | ATIC | - 1.5 | - 2.2 |
Hs.177766 | Poly(ADP-ribose) polymerase | ADPRT | - 1.7 | - 2.0 |
Hs.215766 | GTP-binding protein | GTPBP4 | - 1.5 | - 2.0 |
Hs.409412 | ADP-ribosyltransferase (NAD +; poly(ADP-ribose) polymerase)-like 2 | ADPRTL2 | - 1.5 | - 1.8 |
Hs.2057 | Uridine monophosphate synthetase | UMPS | - 1.5 | - 1.7 |
Hs.383396 | Ribonucleotide reductase M1 polypeptide | RRM1 | - 1.6 | - 1.5 |
Ribosomal/mitochondrial biogenesis | ||||
Hs.411125 | Mitochondrial ribosomal protein S12 | MRPS12 | - 1.7 | - 9.9 |
Hs.435643 | Ts translation elongation factor, mitochondrial | TSFM | - 3.7 | - 6.5 |
Hs.511949 | Ribosomal RNA processing 4 | RRP4 | - 2.0 | - 4.4 |
Hs.71827 | Ribosome biogenesis regulator homolog | RRS1 | - 1.9 | - 3.1 |
Hs.132748 | Ribosomal protein L39 | RPL39 | -1.8 | -2.5 |
Hs.256583 | Interleukin enhancer binding protein 3 | ILF3 | -2.0 | -2.3 |
Hs.511949 | Ribosomal RNA processing 4 | RRP4 | -1.7 | -2.3 |
Hs.101414 | Zinc finger protein 500 | ZNF500 | -1.6 | -2.3 |
Hs.431307 | Mitochondrial ribosomal protein L40 | MRPL40 | -1.6 | -2.1 |
Hs.376064 | Nucleolar protein (KKED repeat) | NOL5A | -1.9 | -2.0 |
Hs.376681 | Mitofusin 2 | MFN2 | -1.7 | -1.7 |
Hs.424264 | Mitochondrial ribosomal protein L46 | MRPL46 | -1.5 | -1.5 |
RNA binding/metabolism | ||||
Hs.443960 | DEAD/H box polypeptide 11 | DDX11 | -4.1 | -3.9 |
Hs.434901 | Small nuclear ribonucleoprotein polypeptide A′ | SNRPA1 | -1.6 | -3.0 |
Hs.166463 | Heterogeneous nuclear ribonucleoprotein U | HNRPU | -1.7 | -2.9 |
Hs.153768 | RNA, U3 small nucleolar interacting protein 2 | RNU3IP2 | -1.7 | -2.4 |
Hs.363492 | DEAD box polypeptide 18 | DDX18 | -1.5 | -2.4 |
Hs.434901 | Small nuclear ribonucleoprotein polypeptide A′ | SNRPA1 | -1.9 | -2.1 |
Hs.416994 | POP7 (processing of precursor) homolog | RPP20 | -1.8 | -2.1 |
Hs.30174 | Small nuclear RNA activating complex 5 | SNAPC5 | -1.7 | -2.1 |
Hs.372673 | Heterogeneous nuclear ribonucleoprotein D-like | HNRPDL | -1.6 | -2.1 |
Hs.130098 | DEAD box polypeptide 23 | DDX23 | -1.5 | -2.1 |
Hs.7174 | DEAH (Asp-Glu-Ala-His) box polypeptide 35 | DHX35 | -2.1 | -2.0 |
Hs.73965 | Splicing factor, arginine/serine-rich 2 | SFRS2 | -1.6 | -2.0 |
Hs.438726 | Heterogeneous nuclear ribonucleoprotein D | HNRPD | -2.2 | -1.9 |
Hs.434901 | Small nuclear ribonucleoprotein polypeptide A′ | SNRPA1 | -1.9 | -1.9 |
Hs.438726 | DEAD box polypeptide 21 | DDX21 | -1.7 | -1.9 |
Hs.372673 | Heterogeneous nuclear ribonucleoprotein D-like | HNRPDL | -1.6 | -1.7 |
Hs.86948 | Small nuclear ribonucleoprotein D1 polypeptide | SNRPD1 | -1.6 | -1.7 |
Hs.356549 | Small nuclear ribonucleoprotein D3 polypeptide | SNRPD3 | -1.5 | -1.7 |
Hs.511756 | Ribonuclease P1 | RNASEP1 | -1.6 | -1.6 |
Hs.139120 | Ribonuclease P (30 kDa) | RPP30 | -1.6 | -1.6 |
Ubiquitin/proteasome | ||||
Hs.152978 | Proteasome activator subunit 3 | PSME3 | -1.6 | -2.9 |
Hs.396393 | Ubiquitin-conjugating enzyme E2S | UBE2S | -1.6 | -2.9 |
Hs.25223 | Ubiquitin carboxyl-terminal hydrolase L5 | UCHL5 | -1.6 | -2.1 |
Hs.443379 | Proteasome 26S subunit, non-ATPase, 11 | PSMD11 | -1.5 | -2.1 |
Hs.152978 | Proteasome activator subunit 3 | PSME3 | -1.6 | -1.8 |
Hs.119563 | Proteasome activator subunit 4 | PSME4 | -1.6 | -1.8 |
Hs.12820 | Ubiquitin specific protease 39 | USP39 | -1.6 | -1.6 |
Hs.35086 | Ubiquitin specific protease 1 | USP1 | -1.5 | -1.5 |
Transcription factors | ||||
Hs.446451 | Myeloid/lymphoid leukemia; translocated to, 10 | MLLT10 | -2.2 | -5.1 |
Hs.54089 | BRCA1 associated RING domain 1 | BARD1 | -1.6 | -3.6 |
Hs.194143 | Breast cancer 1, early onset | BRCA1 | -2.7 | -3.2 |
Hs.181128 | ELK1, member of ETS oncogene family | ELK1 | -2.4 | -3.0 |
Hs.75133 | Transcription factor A, mitochondrial | TFAM | -1.6 | -3.0 |
Hs.448398 | MYC-associated zinc finger protein | MAZ | -1.6 | -2.8 |
Hs.194143 | Breast cancer 1, early onset | BRCA1 | -2.0 | -2.4 |
Hs.106415 | Peroxisome proliferative activated receptor, delta | PPARD | -2.1 | -2.3 |
Hs.408528 | Retinoblastoma 1 | RB1 | -1.8 | -2.3 |
Hs.436187 | Thyroid hormone receptor interactor 13 | TRIP13 | -1.9 | -2.1 |
Hs.75133 | Transcription factor 6-like 1 | TF6M | -1.6 | -1.7 |
Hs.75133 | Transcription factor A, mitochondrial | TFAM | -1.6 | -1.7 |
Hs.410900 | Inhibitor of DNA binding 1 | ID1 | -1.6 | -1.5 |
Unigene . | Gene name . | Symbol . | Hypoxia . | AdCA5 . |
---|---|---|---|---|
CDC/cyclins | ||||
Hs.408658 | Cyclin E2 | CCNE2 | - 1.7 | - 4.1 |
Hs.244723 | Cyclin E1 | CCNE1 | - 1.9 | - 3.9 |
Hs.1973 | Cyclin F | CCNF | - 2.1 | - 3.0 |
Hs.408658 | Cyclin E2 | CCNE2 | - 2.4 | - 2.8 |
Hs.334562 | Cell division cycle 2 | CDC2 | - 1.5 | - 2.2 |
Hs.405958 | Cell division cycle 6 | CDC6 | - 2.7 | - 2.1 |
Hs.334562 | Cell division cycle 2 | CDC2 | - 1.8 | - 2.1 |
Hs.28853 | Cell division cycle 7 | CDC7 | - 1.6 | - 2.1 |
Hs.334562 | Cell division cycle 2 | CDC2 | - 1.8 | - 1.9 |
MCM proteins | ||||
Hs.460184 | Minichromosome maintenance deficient 4 | MCM4 | - 2.4 | - 3.1 |
Hs.460184 | Minichromosome maintenance deficient 4 | MCM4 | - 2.2 | - 3.1 |
Hs.57101 | Minichromosome maintenance deficient 2 | MCM2 | - 2.2 | - 3.1 |
Hs.77171 | Minichromosome maintenance deficient 5 | MCM5 | - 2.4 | - 2.7 |
Hs.444118 | Minichromosome maintenance deficient 6 | MCM6 | - 1.9 | - 2.4 |
Hs.198363 | Minichromosome maintenance deficient 10 | MCM10 | - 2.2 | - 2.3 |
Hs.179565 | Minichromosome maintenance deficient 3 | MCM3 | - 1.5 | - 2.2 |
Hs.460184 | Minichromosome maintenance deficient 4 | MCM4 | - 1.8 | - 2.1 |
Hs.460184 | Minichromosome maintenance deficient 4 | MCM4 | - 2.0 | - 1.8 |
DNA/RNA polymerases | ||||
Hs.437186 | Polymerase (RNA) III polypeptide K | POLR3K | - 2.1 | - 4.3 |
Hs.441072 | Polymerase (RNA) II polypeptide L | RNAPOL2 | - 2.0 | - 3.3 |
Hs.99185 | Polymerase (DNA directed), epsilon 2 | POLE2 | - 2.0 | - 2.6 |
Hs.282387 | Polymerase (RNA) III (32kD) | RPC32 | - 1.9 | - 1.9 |
Hs.306791 | Polymerase (DNA directed), delta 2 | POLD2 | - 1.5 | - 1.7 |
Hs.290921 | Polymerase (DNA directed), gamma | POLG | - 1.7 | - 1.6 |
Replication factors | ||||
Hs.79018 | Chromatin assembly factor 1, subunit A | CHAF1A | - 6.0 | - 10.0 |
Hs.433180 | DNA replication complex GINS protein PSF2 | PFS2 | - 2.2 | - 3.4 |
Hs.194665 | DNA replication helicase 2-like | DNA2L | - 1.7 | - 3.3 |
Hs.443227 | Replication factor C5 | RFC5 | - 1.9 | - 3.2 |
Hs.115474 | Replication factor C (activator 1) 3 | RFC3 | - 1.9 | - 2.9 |
Hs.443227 | Replication factor C5 | RFC5 | - 1.6 | - 2.3 |
Hs.49760 | Origin recognition complex, subunit 6-like | ORC6L | - 1.9 | - 1.9 |
Hs.139226 | Replication factor C (activator 1) 2 | RFC2 | - 1.6 | - 1.6 |
Other cell cycle | ||||
Hs.23348 | S-phase kinase-associated protein 2 | SKP2 | - 2.4 | - 3.1 |
Hs.79078 | MAD2 mitotic arrest deficient-like 1 | MAD2L1 | - 1.7 | - 2.9 |
Hs.511945 | Block of proliferation 1 | BOP1 | - 1.7 | - 2.8 |
Hs.42650 | ZW10 interactor | ZWINT | - 2.0 | - 2.5 |
Hs.445084 | M-phase phosphoprotein 9 | MPHOSPH9 | - 1.7 | - 2.5 |
Hs.75337 | Nucleolar and coiled-body phosphoprotein 1 | NOLC1 | - 1.6 | - 2.4 |
Hs.374491 | Proliferation-associated 2G4 | PA2G4 | - 1.6 | - 2.1 |
Hs.152759 | Activator of S-phase kinase | ASK | - 2.7 | - 2.0 |
Hs.344037 | Protein regulator of cytokinesis 1 | PRC1 | - 2.0 | - 1.6 |
Hs.433008 | NIMA (never in mitosis a)-related kinase 4 | NEK4 | - 1.5 | - 1.5 |
Ribonucleotide metabolism | ||||
Hs.226390 | Ribonucleotide reductase M2 polypeptide | RRM2 | - 2.4 | - 7.2 |
Hs.464813 | Dihydrofolate reductase | DHFR | - 2.0 | - 4.5 |
Hs.251871 | CTP synthase | CTPS | - 1.8 | - 3.2 |
Hs.226390 | Ribonucleotide reductase M2 polypeptide | RRM2 | - 1.8 | - 2.4 |
Hs.56 | Phosphoribosyl pyrophosphate synthetase 1 | PRPS1 | - 1.6 | - 2.3 |
Hs.2057 | Uridine monophosphate synthetase | UMPS | - 1.6 | - 2.3 |
Hs.464813 | Dihydrofolate reductase | DHFR | - 1.5 | - 2.3 |
Hs.90280 | 5-aminoimidazole-4-carboxamide ribonucleotide transformylase | ATIC | - 1.5 | - 2.2 |
Hs.177766 | Poly(ADP-ribose) polymerase | ADPRT | - 1.7 | - 2.0 |
Hs.215766 | GTP-binding protein | GTPBP4 | - 1.5 | - 2.0 |
Hs.409412 | ADP-ribosyltransferase (NAD +; poly(ADP-ribose) polymerase)-like 2 | ADPRTL2 | - 1.5 | - 1.8 |
Hs.2057 | Uridine monophosphate synthetase | UMPS | - 1.5 | - 1.7 |
Hs.383396 | Ribonucleotide reductase M1 polypeptide | RRM1 | - 1.6 | - 1.5 |
Ribosomal/mitochondrial biogenesis | ||||
Hs.411125 | Mitochondrial ribosomal protein S12 | MRPS12 | - 1.7 | - 9.9 |
Hs.435643 | Ts translation elongation factor, mitochondrial | TSFM | - 3.7 | - 6.5 |
Hs.511949 | Ribosomal RNA processing 4 | RRP4 | - 2.0 | - 4.4 |
Hs.71827 | Ribosome biogenesis regulator homolog | RRS1 | - 1.9 | - 3.1 |
Hs.132748 | Ribosomal protein L39 | RPL39 | -1.8 | -2.5 |
Hs.256583 | Interleukin enhancer binding protein 3 | ILF3 | -2.0 | -2.3 |
Hs.511949 | Ribosomal RNA processing 4 | RRP4 | -1.7 | -2.3 |
Hs.101414 | Zinc finger protein 500 | ZNF500 | -1.6 | -2.3 |
Hs.431307 | Mitochondrial ribosomal protein L40 | MRPL40 | -1.6 | -2.1 |
Hs.376064 | Nucleolar protein (KKED repeat) | NOL5A | -1.9 | -2.0 |
Hs.376681 | Mitofusin 2 | MFN2 | -1.7 | -1.7 |
Hs.424264 | Mitochondrial ribosomal protein L46 | MRPL46 | -1.5 | -1.5 |
RNA binding/metabolism | ||||
Hs.443960 | DEAD/H box polypeptide 11 | DDX11 | -4.1 | -3.9 |
Hs.434901 | Small nuclear ribonucleoprotein polypeptide A′ | SNRPA1 | -1.6 | -3.0 |
Hs.166463 | Heterogeneous nuclear ribonucleoprotein U | HNRPU | -1.7 | -2.9 |
Hs.153768 | RNA, U3 small nucleolar interacting protein 2 | RNU3IP2 | -1.7 | -2.4 |
Hs.363492 | DEAD box polypeptide 18 | DDX18 | -1.5 | -2.4 |
Hs.434901 | Small nuclear ribonucleoprotein polypeptide A′ | SNRPA1 | -1.9 | -2.1 |
Hs.416994 | POP7 (processing of precursor) homolog | RPP20 | -1.8 | -2.1 |
Hs.30174 | Small nuclear RNA activating complex 5 | SNAPC5 | -1.7 | -2.1 |
Hs.372673 | Heterogeneous nuclear ribonucleoprotein D-like | HNRPDL | -1.6 | -2.1 |
Hs.130098 | DEAD box polypeptide 23 | DDX23 | -1.5 | -2.1 |
Hs.7174 | DEAH (Asp-Glu-Ala-His) box polypeptide 35 | DHX35 | -2.1 | -2.0 |
Hs.73965 | Splicing factor, arginine/serine-rich 2 | SFRS2 | -1.6 | -2.0 |
Hs.438726 | Heterogeneous nuclear ribonucleoprotein D | HNRPD | -2.2 | -1.9 |
Hs.434901 | Small nuclear ribonucleoprotein polypeptide A′ | SNRPA1 | -1.9 | -1.9 |
Hs.438726 | DEAD box polypeptide 21 | DDX21 | -1.7 | -1.9 |
Hs.372673 | Heterogeneous nuclear ribonucleoprotein D-like | HNRPDL | -1.6 | -1.7 |
Hs.86948 | Small nuclear ribonucleoprotein D1 polypeptide | SNRPD1 | -1.6 | -1.7 |
Hs.356549 | Small nuclear ribonucleoprotein D3 polypeptide | SNRPD3 | -1.5 | -1.7 |
Hs.511756 | Ribonuclease P1 | RNASEP1 | -1.6 | -1.6 |
Hs.139120 | Ribonuclease P (30 kDa) | RPP30 | -1.6 | -1.6 |
Ubiquitin/proteasome | ||||
Hs.152978 | Proteasome activator subunit 3 | PSME3 | -1.6 | -2.9 |
Hs.396393 | Ubiquitin-conjugating enzyme E2S | UBE2S | -1.6 | -2.9 |
Hs.25223 | Ubiquitin carboxyl-terminal hydrolase L5 | UCHL5 | -1.6 | -2.1 |
Hs.443379 | Proteasome 26S subunit, non-ATPase, 11 | PSMD11 | -1.5 | -2.1 |
Hs.152978 | Proteasome activator subunit 3 | PSME3 | -1.6 | -1.8 |
Hs.119563 | Proteasome activator subunit 4 | PSME4 | -1.6 | -1.8 |
Hs.12820 | Ubiquitin specific protease 39 | USP39 | -1.6 | -1.6 |
Hs.35086 | Ubiquitin specific protease 1 | USP1 | -1.5 | -1.5 |
Transcription factors | ||||
Hs.446451 | Myeloid/lymphoid leukemia; translocated to, 10 | MLLT10 | -2.2 | -5.1 |
Hs.54089 | BRCA1 associated RING domain 1 | BARD1 | -1.6 | -3.6 |
Hs.194143 | Breast cancer 1, early onset | BRCA1 | -2.7 | -3.2 |
Hs.181128 | ELK1, member of ETS oncogene family | ELK1 | -2.4 | -3.0 |
Hs.75133 | Transcription factor A, mitochondrial | TFAM | -1.6 | -3.0 |
Hs.448398 | MYC-associated zinc finger protein | MAZ | -1.6 | -2.8 |
Hs.194143 | Breast cancer 1, early onset | BRCA1 | -2.0 | -2.4 |
Hs.106415 | Peroxisome proliferative activated receptor, delta | PPARD | -2.1 | -2.3 |
Hs.408528 | Retinoblastoma 1 | RB1 | -1.8 | -2.3 |
Hs.436187 | Thyroid hormone receptor interactor 13 | TRIP13 | -1.9 | -2.1 |
Hs.75133 | Transcription factor 6-like 1 | TF6M | -1.6 | -1.7 |
Hs.75133 | Transcription factor A, mitochondrial | TFAM | -1.6 | -1.7 |
Hs.410900 | Inhibitor of DNA binding 1 | ID1 | -1.6 | -1.5 |