Table 2.

Selected genes repressed by both hypoxia and AdCA5


Unigene

Gene name

Symbol

Hypoxia

AdCA5
CDC/cyclins     
    Hs.408658   Cyclin E2  CCNE2  - 1.7   - 4.1  
    Hs.244723   Cyclin E1  CCNE1  - 1.9   - 3.9  
    Hs.1973   Cyclin F  CCNF  - 2.1   - 3.0  
    Hs.408658   Cyclin E2  CCNE2  - 2.4   - 2.8  
    Hs.334562   Cell division cycle 2  CDC2  - 1.5   - 2.2  
    Hs.405958   Cell division cycle 6  CDC6  - 2.7   - 2.1  
    Hs.334562   Cell division cycle 2  CDC2  - 1.8   - 2.1  
    Hs.28853   Cell division cycle 7  CDC7  - 1.6   - 2.1  
    Hs.334562   Cell division cycle 2  CDC2  - 1.8   - 1.9  
MCM proteins     
    Hs.460184   Minichromosome maintenance deficient 4  MCM4  - 2.4   - 3.1  
    Hs.460184   Minichromosome maintenance deficient 4  MCM4  - 2.2   - 3.1  
    Hs.57101   Minichromosome maintenance deficient 2  MCM2  - 2.2   - 3.1  
    Hs.77171   Minichromosome maintenance deficient 5  MCM5  - 2.4   - 2.7  
    Hs.444118   Minichromosome maintenance deficient 6  MCM6  - 1.9   - 2.4  
    Hs.198363   Minichromosome maintenance deficient 10  MCM10  - 2.2   - 2.3  
    Hs.179565   Minichromosome maintenance deficient 3  MCM3  - 1.5   - 2.2  
    Hs.460184   Minichromosome maintenance deficient 4  MCM4  - 1.8   - 2.1  
    Hs.460184   Minichromosome maintenance deficient 4  MCM4  - 2.0   - 1.8  
DNA/RNA polymerases     
    Hs.437186   Polymerase (RNA) III polypeptide K  POLR3K  - 2.1   - 4.3  
    Hs.441072   Polymerase (RNA) II polypeptide L  RNAPOL2  - 2.0   - 3.3  
    Hs.99185   Polymerase (DNA directed), epsilon 2  POLE2  - 2.0   - 2.6  
    Hs.282387   Polymerase (RNA) III (32kD)  RPC32  - 1.9   - 1.9  
    Hs.306791   Polymerase (DNA directed), delta 2  POLD2  - 1.5   - 1.7  
    Hs.290921   Polymerase (DNA directed), gamma  POLG  - 1.7   - 1.6  
Replication factors     
    Hs.79018   Chromatin assembly factor 1, subunit A  CHAF1A  - 6.0   - 10.0  
    Hs.433180   DNA replication complex GINS protein PSF2  PFS2  - 2.2   - 3.4  
    Hs.194665   DNA replication helicase 2-like  DNA2L  - 1.7   - 3.3  
    Hs.443227   Replication factor C5  RFC5  - 1.9   - 3.2  
    Hs.115474   Replication factor C (activator 1) 3  RFC3  - 1.9   - 2.9  
    Hs.443227   Replication factor C5  RFC5  - 1.6   - 2.3  
    Hs.49760   Origin recognition complex, subunit 6-like  ORC6L  - 1.9   - 1.9  
    Hs.139226   Replication factor C (activator 1) 2  RFC2  - 1.6   - 1.6  
Other cell cycle     
    Hs.23348   S-phase kinase-associated protein 2  SKP2  - 2.4   - 3.1  
    Hs.79078   MAD2 mitotic arrest deficient-like 1  MAD2L1  - 1.7   - 2.9  
    Hs.511945   Block of proliferation 1  BOP1  - 1.7   - 2.8  
    Hs.42650   ZW10 interactor  ZWINT  - 2.0   - 2.5  
    Hs.445084   M-phase phosphoprotein 9  MPHOSPH9  - 1.7   - 2.5  
    Hs.75337   Nucleolar and coiled-body phosphoprotein 1  NOLC1  - 1.6   - 2.4  
    Hs.374491   Proliferation-associated 2G4  PA2G4  - 1.6   - 2.1  
    Hs.152759   Activator of S-phase kinase  ASK  - 2.7   - 2.0  
    Hs.344037   Protein regulator of cytokinesis 1  PRC1  - 2.0   - 1.6  
    Hs.433008   NIMA (never in mitosis a)-related kinase 4  NEK4  - 1.5   - 1.5  
Ribonucleotide metabolism     
    Hs.226390   Ribonucleotide reductase M2 polypeptide  RRM2  - 2.4   - 7.2  
    Hs.464813   Dihydrofolate reductase  DHFR  - 2.0   - 4.5  
    Hs.251871   CTP synthase  CTPS  - 1.8   - 3.2  
    Hs.226390   Ribonucleotide reductase M2 polypeptide  RRM2  - 1.8   - 2.4  
    Hs.56   Phosphoribosyl pyrophosphate synthetase 1  PRPS1  - 1.6   - 2.3  
    Hs.2057   Uridine monophosphate synthetase  UMPS  - 1.6   - 2.3  
    Hs.464813   Dihydrofolate reductase  DHFR  - 1.5   - 2.3  
    Hs.90280   5-aminoimidazole-4-carboxamide ribonucleotide transformylase  ATIC  - 1.5   - 2.2  
    Hs.177766   Poly(ADP-ribose) polymerase  ADPRT  - 1.7   - 2.0  
    Hs.215766   GTP-binding protein  GTPBP4  - 1.5   - 2.0  
    Hs.409412   ADP-ribosyltransferase (NAD +; poly(ADP-ribose) polymerase)-like 2  ADPRTL2  - 1.5   - 1.8  
    Hs.2057   Uridine monophosphate synthetase  UMPS  - 1.5   - 1.7  
    Hs.383396   Ribonucleotide reductase M1 polypeptide  RRM1  - 1.6   - 1.5  
Ribosomal/mitochondrial biogenesis     
    Hs.411125   Mitochondrial ribosomal protein S12  MRPS12  - 1.7   - 9.9  
    Hs.435643   Ts translation elongation factor, mitochondrial  TSFM  - 3.7   - 6.5  
    Hs.511949   Ribosomal RNA processing 4  RRP4  - 2.0   - 4.4  
    Hs.71827   Ribosome biogenesis regulator homolog  RRS1  - 1.9   - 3.1  
    Hs.132748   Ribosomal protein L39  RPL39  -1.8   -2.5  
    Hs.256583   Interleukin enhancer binding protein 3  ILF3  -2.0   -2.3  
    Hs.511949   Ribosomal RNA processing 4  RRP4  -1.7   -2.3  
    Hs.101414   Zinc finger protein 500  ZNF500  -1.6   -2.3  
    Hs.431307   Mitochondrial ribosomal protein L40  MRPL40  -1.6   -2.1  
    Hs.376064   Nucleolar protein (KKED repeat)  NOL5A  -1.9   -2.0  
    Hs.376681   Mitofusin 2  MFN2  -1.7   -1.7  
    Hs.424264   Mitochondrial ribosomal protein L46  MRPL46  -1.5   -1.5  
RNA binding/metabolism     
    Hs.443960   DEAD/H box polypeptide 11  DDX11  -4.1   -3.9  
    Hs.434901   Small nuclear ribonucleoprotein polypeptide A′  SNRPA1  -1.6   -3.0  
    Hs.166463   Heterogeneous nuclear ribonucleoprotein U  HNRPU  -1.7   -2.9  
    Hs.153768   RNA, U3 small nucleolar interacting protein 2  RNU3IP2  -1.7   -2.4  
    Hs.363492   DEAD box polypeptide 18  DDX18  -1.5   -2.4  
    Hs.434901   Small nuclear ribonucleoprotein polypeptide A′  SNRPA1  -1.9   -2.1  
    Hs.416994   POP7 (processing of precursor) homolog  RPP20  -1.8   -2.1  
    Hs.30174   Small nuclear RNA activating complex 5  SNAPC5  -1.7   -2.1  
    Hs.372673   Heterogeneous nuclear ribonucleoprotein D-like  HNRPDL  -1.6   -2.1  
    Hs.130098   DEAD box polypeptide 23  DDX23  -1.5   -2.1  
    Hs.7174   DEAH (Asp-Glu-Ala-His) box polypeptide 35  DHX35  -2.1   -2.0  
    Hs.73965   Splicing factor, arginine/serine-rich 2  SFRS2  -1.6   -2.0  
    Hs.438726   Heterogeneous nuclear ribonucleoprotein D  HNRPD  -2.2   -1.9  
    Hs.434901   Small nuclear ribonucleoprotein polypeptide A′  SNRPA1  -1.9   -1.9  
    Hs.438726   DEAD box polypeptide 21  DDX21  -1.7   -1.9  
    Hs.372673   Heterogeneous nuclear ribonucleoprotein D-like  HNRPDL  -1.6   -1.7  
    Hs.86948   Small nuclear ribonucleoprotein D1 polypeptide  SNRPD1  -1.6   -1.7  
    Hs.356549   Small nuclear ribonucleoprotein D3 polypeptide  SNRPD3  -1.5   -1.7  
    Hs.511756   Ribonuclease P1  RNASEP1  -1.6   -1.6  
    Hs.139120   Ribonuclease P (30 kDa)  RPP30  -1.6   -1.6  
Ubiquitin/proteasome     
    Hs.152978   Proteasome activator subunit 3  PSME3  -1.6   -2.9  
    Hs.396393   Ubiquitin-conjugating enzyme E2S  UBE2S  -1.6   -2.9  
    Hs.25223   Ubiquitin carboxyl-terminal hydrolase L5  UCHL5  -1.6   -2.1  
    Hs.443379   Proteasome 26S subunit, non-ATPase, 11  PSMD11  -1.5   -2.1  
    Hs.152978   Proteasome activator subunit 3  PSME3  -1.6   -1.8  
    Hs.119563   Proteasome activator subunit 4  PSME4  -1.6   -1.8  
    Hs.12820   Ubiquitin specific protease 39  USP39  -1.6   -1.6  
    Hs.35086   Ubiquitin specific protease 1  USP1  -1.5   -1.5  
Transcription factors     
    Hs.446451   Myeloid/lymphoid leukemia; translocated to, 10  MLLT10  -2.2   -5.1  
    Hs.54089   BRCA1 associated RING domain 1  BARD1  -1.6   -3.6  
    Hs.194143   Breast cancer 1, early onset  BRCA1  -2.7   -3.2  
    Hs.181128   ELK1, member of ETS oncogene family  ELK1  -2.4   -3.0  
    Hs.75133   Transcription factor A, mitochondrial  TFAM  -1.6   -3.0  
    Hs.448398   MYC-associated zinc finger protein  MAZ  -1.6   -2.8  
    Hs.194143   Breast cancer 1, early onset  BRCA1  -2.0   -2.4  
    Hs.106415   Peroxisome proliferative activated receptor, delta  PPARD  -2.1   -2.3  
    Hs.408528   Retinoblastoma 1  RB1  -1.8   -2.3  
    Hs.436187   Thyroid hormone receptor interactor 13  TRIP13  -1.9   -2.1  
    Hs.75133   Transcription factor 6-like 1  TF6M  -1.6   -1.7  
    Hs.75133   Transcription factor A, mitochondrial  TFAM  -1.6   -1.7  
    Hs.410900
 
Inhibitor of DNA binding 1
 
ID1
 
-1.6
 
-1.5
 

Unigene

Gene name

Symbol

Hypoxia

AdCA5
CDC/cyclins     
    Hs.408658   Cyclin E2  CCNE2  - 1.7   - 4.1  
    Hs.244723   Cyclin E1  CCNE1  - 1.9   - 3.9  
    Hs.1973   Cyclin F  CCNF  - 2.1   - 3.0  
    Hs.408658   Cyclin E2  CCNE2  - 2.4   - 2.8  
    Hs.334562   Cell division cycle 2  CDC2  - 1.5   - 2.2  
    Hs.405958   Cell division cycle 6  CDC6  - 2.7   - 2.1  
    Hs.334562   Cell division cycle 2  CDC2  - 1.8   - 2.1  
    Hs.28853   Cell division cycle 7  CDC7  - 1.6   - 2.1  
    Hs.334562   Cell division cycle 2  CDC2  - 1.8   - 1.9  
MCM proteins     
    Hs.460184   Minichromosome maintenance deficient 4  MCM4  - 2.4   - 3.1  
    Hs.460184   Minichromosome maintenance deficient 4  MCM4  - 2.2   - 3.1  
    Hs.57101   Minichromosome maintenance deficient 2  MCM2  - 2.2   - 3.1  
    Hs.77171   Minichromosome maintenance deficient 5  MCM5  - 2.4   - 2.7  
    Hs.444118   Minichromosome maintenance deficient 6  MCM6  - 1.9   - 2.4  
    Hs.198363   Minichromosome maintenance deficient 10  MCM10  - 2.2   - 2.3  
    Hs.179565   Minichromosome maintenance deficient 3  MCM3  - 1.5   - 2.2  
    Hs.460184   Minichromosome maintenance deficient 4  MCM4  - 1.8   - 2.1  
    Hs.460184   Minichromosome maintenance deficient 4  MCM4  - 2.0   - 1.8  
DNA/RNA polymerases     
    Hs.437186   Polymerase (RNA) III polypeptide K  POLR3K  - 2.1   - 4.3  
    Hs.441072   Polymerase (RNA) II polypeptide L  RNAPOL2  - 2.0   - 3.3  
    Hs.99185   Polymerase (DNA directed), epsilon 2  POLE2  - 2.0   - 2.6  
    Hs.282387   Polymerase (RNA) III (32kD)  RPC32  - 1.9   - 1.9  
    Hs.306791   Polymerase (DNA directed), delta 2  POLD2  - 1.5   - 1.7  
    Hs.290921   Polymerase (DNA directed), gamma  POLG  - 1.7   - 1.6  
Replication factors     
    Hs.79018   Chromatin assembly factor 1, subunit A  CHAF1A  - 6.0   - 10.0  
    Hs.433180   DNA replication complex GINS protein PSF2  PFS2  - 2.2   - 3.4  
    Hs.194665   DNA replication helicase 2-like  DNA2L  - 1.7   - 3.3  
    Hs.443227   Replication factor C5  RFC5  - 1.9   - 3.2  
    Hs.115474   Replication factor C (activator 1) 3  RFC3  - 1.9   - 2.9  
    Hs.443227   Replication factor C5  RFC5  - 1.6   - 2.3  
    Hs.49760   Origin recognition complex, subunit 6-like  ORC6L  - 1.9   - 1.9  
    Hs.139226   Replication factor C (activator 1) 2  RFC2  - 1.6   - 1.6  
Other cell cycle     
    Hs.23348   S-phase kinase-associated protein 2  SKP2  - 2.4   - 3.1  
    Hs.79078   MAD2 mitotic arrest deficient-like 1  MAD2L1  - 1.7   - 2.9  
    Hs.511945   Block of proliferation 1  BOP1  - 1.7   - 2.8  
    Hs.42650   ZW10 interactor  ZWINT  - 2.0   - 2.5  
    Hs.445084   M-phase phosphoprotein 9  MPHOSPH9  - 1.7   - 2.5  
    Hs.75337   Nucleolar and coiled-body phosphoprotein 1  NOLC1  - 1.6   - 2.4  
    Hs.374491   Proliferation-associated 2G4  PA2G4  - 1.6   - 2.1  
    Hs.152759   Activator of S-phase kinase  ASK  - 2.7   - 2.0  
    Hs.344037   Protein regulator of cytokinesis 1  PRC1  - 2.0   - 1.6  
    Hs.433008   NIMA (never in mitosis a)-related kinase 4  NEK4  - 1.5   - 1.5  
Ribonucleotide metabolism     
    Hs.226390   Ribonucleotide reductase M2 polypeptide  RRM2  - 2.4   - 7.2  
    Hs.464813   Dihydrofolate reductase  DHFR  - 2.0   - 4.5  
    Hs.251871   CTP synthase  CTPS  - 1.8   - 3.2  
    Hs.226390   Ribonucleotide reductase M2 polypeptide  RRM2  - 1.8   - 2.4  
    Hs.56   Phosphoribosyl pyrophosphate synthetase 1  PRPS1  - 1.6   - 2.3  
    Hs.2057   Uridine monophosphate synthetase  UMPS  - 1.6   - 2.3  
    Hs.464813   Dihydrofolate reductase  DHFR  - 1.5   - 2.3  
    Hs.90280   5-aminoimidazole-4-carboxamide ribonucleotide transformylase  ATIC  - 1.5   - 2.2  
    Hs.177766   Poly(ADP-ribose) polymerase  ADPRT  - 1.7   - 2.0  
    Hs.215766   GTP-binding protein  GTPBP4  - 1.5   - 2.0  
    Hs.409412   ADP-ribosyltransferase (NAD +; poly(ADP-ribose) polymerase)-like 2  ADPRTL2  - 1.5   - 1.8  
    Hs.2057   Uridine monophosphate synthetase  UMPS  - 1.5   - 1.7  
    Hs.383396   Ribonucleotide reductase M1 polypeptide  RRM1  - 1.6   - 1.5  
Ribosomal/mitochondrial biogenesis     
    Hs.411125   Mitochondrial ribosomal protein S12  MRPS12  - 1.7   - 9.9  
    Hs.435643   Ts translation elongation factor, mitochondrial  TSFM  - 3.7   - 6.5  
    Hs.511949   Ribosomal RNA processing 4  RRP4  - 2.0   - 4.4  
    Hs.71827   Ribosome biogenesis regulator homolog  RRS1  - 1.9   - 3.1  
    Hs.132748   Ribosomal protein L39  RPL39  -1.8   -2.5  
    Hs.256583   Interleukin enhancer binding protein 3  ILF3  -2.0   -2.3  
    Hs.511949   Ribosomal RNA processing 4  RRP4  -1.7   -2.3  
    Hs.101414   Zinc finger protein 500  ZNF500  -1.6   -2.3  
    Hs.431307   Mitochondrial ribosomal protein L40  MRPL40  -1.6   -2.1  
    Hs.376064   Nucleolar protein (KKED repeat)  NOL5A  -1.9   -2.0  
    Hs.376681   Mitofusin 2  MFN2  -1.7   -1.7  
    Hs.424264   Mitochondrial ribosomal protein L46  MRPL46  -1.5   -1.5  
RNA binding/metabolism     
    Hs.443960   DEAD/H box polypeptide 11  DDX11  -4.1   -3.9  
    Hs.434901   Small nuclear ribonucleoprotein polypeptide A′  SNRPA1  -1.6   -3.0  
    Hs.166463   Heterogeneous nuclear ribonucleoprotein U  HNRPU  -1.7   -2.9  
    Hs.153768   RNA, U3 small nucleolar interacting protein 2  RNU3IP2  -1.7   -2.4  
    Hs.363492   DEAD box polypeptide 18  DDX18  -1.5   -2.4  
    Hs.434901   Small nuclear ribonucleoprotein polypeptide A′  SNRPA1  -1.9   -2.1  
    Hs.416994   POP7 (processing of precursor) homolog  RPP20  -1.8   -2.1  
    Hs.30174   Small nuclear RNA activating complex 5  SNAPC5  -1.7   -2.1  
    Hs.372673   Heterogeneous nuclear ribonucleoprotein D-like  HNRPDL  -1.6   -2.1  
    Hs.130098   DEAD box polypeptide 23  DDX23  -1.5   -2.1  
    Hs.7174   DEAH (Asp-Glu-Ala-His) box polypeptide 35  DHX35  -2.1   -2.0  
    Hs.73965   Splicing factor, arginine/serine-rich 2  SFRS2  -1.6   -2.0  
    Hs.438726   Heterogeneous nuclear ribonucleoprotein D  HNRPD  -2.2   -1.9  
    Hs.434901   Small nuclear ribonucleoprotein polypeptide A′  SNRPA1  -1.9   -1.9  
    Hs.438726   DEAD box polypeptide 21  DDX21  -1.7   -1.9  
    Hs.372673   Heterogeneous nuclear ribonucleoprotein D-like  HNRPDL  -1.6   -1.7  
    Hs.86948   Small nuclear ribonucleoprotein D1 polypeptide  SNRPD1  -1.6   -1.7  
    Hs.356549   Small nuclear ribonucleoprotein D3 polypeptide  SNRPD3  -1.5   -1.7  
    Hs.511756   Ribonuclease P1  RNASEP1  -1.6   -1.6  
    Hs.139120   Ribonuclease P (30 kDa)  RPP30  -1.6   -1.6  
Ubiquitin/proteasome     
    Hs.152978   Proteasome activator subunit 3  PSME3  -1.6   -2.9  
    Hs.396393   Ubiquitin-conjugating enzyme E2S  UBE2S  -1.6   -2.9  
    Hs.25223   Ubiquitin carboxyl-terminal hydrolase L5  UCHL5  -1.6   -2.1  
    Hs.443379   Proteasome 26S subunit, non-ATPase, 11  PSMD11  -1.5   -2.1  
    Hs.152978   Proteasome activator subunit 3  PSME3  -1.6   -1.8  
    Hs.119563   Proteasome activator subunit 4  PSME4  -1.6   -1.8  
    Hs.12820   Ubiquitin specific protease 39  USP39  -1.6   -1.6  
    Hs.35086   Ubiquitin specific protease 1  USP1  -1.5   -1.5  
Transcription factors     
    Hs.446451   Myeloid/lymphoid leukemia; translocated to, 10  MLLT10  -2.2   -5.1  
    Hs.54089   BRCA1 associated RING domain 1  BARD1  -1.6   -3.6  
    Hs.194143   Breast cancer 1, early onset  BRCA1  -2.7   -3.2  
    Hs.181128   ELK1, member of ETS oncogene family  ELK1  -2.4   -3.0  
    Hs.75133   Transcription factor A, mitochondrial  TFAM  -1.6   -3.0  
    Hs.448398   MYC-associated zinc finger protein  MAZ  -1.6   -2.8  
    Hs.194143   Breast cancer 1, early onset  BRCA1  -2.0   -2.4  
    Hs.106415   Peroxisome proliferative activated receptor, delta  PPARD  -2.1   -2.3  
    Hs.408528   Retinoblastoma 1  RB1  -1.8   -2.3  
    Hs.436187   Thyroid hormone receptor interactor 13  TRIP13  -1.9   -2.1  
    Hs.75133   Transcription factor 6-like 1  TF6M  -1.6   -1.7  
    Hs.75133   Transcription factor A, mitochondrial  TFAM  -1.6   -1.7  
    Hs.410900
 
Inhibitor of DNA binding 1
 
ID1
 
-1.6
 
-1.5
 

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