Characterization of splice variants and mutant forms of the FANCD2 protein compared with wild-type FANCD2
. | Monoubiquitin on K561 . | Detected in chromatin . | Forms nuclear foci . | Corrects MMC sensitivity . |
|---|---|---|---|---|
| FANCD2-43 | + | ND | + | - |
| FANCD2-44 | +* | + | +* | +* |
| Exon44-T | + | + | + | - |
| Mutant EDGE, D1428A | + | + | + | - |
| K561R | -* | - | -* | -* |
. | Monoubiquitin on K561 . | Detected in chromatin . | Forms nuclear foci . | Corrects MMC sensitivity . |
|---|---|---|---|---|
| FANCD2-43 | + | ND | + | - |
| FANCD2-44 | +* | + | +* | +* |
| Exon44-T | + | + | + | - |
| Mutant EDGE, D1428A | + | + | + | - |
| K561R | -* | - | -* | -* |
ND indicates not determined.
Data reported in Garcia-Higuera et al.10