Toxicity observed in patients with AML treated with depsipeptide
Toxicity . | Grade 1, no. . | Grade 2, no. . | Grade 3, no. . | Grade 4, no. . |
|---|---|---|---|---|
| Anorexia | 5 | 4 | 1 | NA |
| Fatigue | 4 | 3 | 2 | NA |
| Nausea | 2 | 5 | 1 | NA |
| Vomiting | 4 | 4 | NA | NA |
| Myalgias | 4 | 1 | 1 | NA |
| Headache | 2 | 1 | NA | NA |
| Diarrhea | 3 | 1 | 1 | NA |
| Headache | 2 | 1 | NA | NA |
| Petechiae | 1 | NA | NA | NA |
| Taste loss | 3 | NA | NA | NA |
| Stomatitis | 1 | NA | NA | NA |
| Abdominal pain | NA | NA | 1 | NA |
| Dyspnea | 1 | NA | NA | NA |
| Cough | 2 | NA | NA | NA |
| Chest Pain | 1 | NA | NA | NA |
| Dizziness | 2 | 1 | NA | NA |
| Ataxia | NA | 1 | NA | NA |
| Infection | NA | NA | NA | 1 |
| Epistaxis | 2 | NA | NA | NA |
| Constipation | 2 | NA | NA | NA |
| Ileus | NA | NA | 1 | NA |
| Pruritus | NA | 1 | NA | NA |
| Dehydration | NA | NA | 2 | NA |
| Tumor lysis syndrome | NA | NA | 1 | NA |
| Hypoxia | NA | NA | 1 | NA |
| Hypotension | 3 | 2 | NA | NA |
| Fever | 1 | NA | 2 | NA |
| Catheter-related infection | NA | 1 | NA | NA |
| Arthralgia | 2 | NA | NA | NA |
| Sinus tachycardia | 1 | NA | NA | NA |
| Rigors/chills | 1 | NA | NA | NA |
| Weight loss | 1 | NA | NA | NA |
Toxicity . | Grade 1, no. . | Grade 2, no. . | Grade 3, no. . | Grade 4, no. . |
|---|---|---|---|---|
| Anorexia | 5 | 4 | 1 | NA |
| Fatigue | 4 | 3 | 2 | NA |
| Nausea | 2 | 5 | 1 | NA |
| Vomiting | 4 | 4 | NA | NA |
| Myalgias | 4 | 1 | 1 | NA |
| Headache | 2 | 1 | NA | NA |
| Diarrhea | 3 | 1 | 1 | NA |
| Headache | 2 | 1 | NA | NA |
| Petechiae | 1 | NA | NA | NA |
| Taste loss | 3 | NA | NA | NA |
| Stomatitis | 1 | NA | NA | NA |
| Abdominal pain | NA | NA | 1 | NA |
| Dyspnea | 1 | NA | NA | NA |
| Cough | 2 | NA | NA | NA |
| Chest Pain | 1 | NA | NA | NA |
| Dizziness | 2 | 1 | NA | NA |
| Ataxia | NA | 1 | NA | NA |
| Infection | NA | NA | NA | 1 |
| Epistaxis | 2 | NA | NA | NA |
| Constipation | 2 | NA | NA | NA |
| Ileus | NA | NA | 1 | NA |
| Pruritus | NA | 1 | NA | NA |
| Dehydration | NA | NA | 2 | NA |
| Tumor lysis syndrome | NA | NA | 1 | NA |
| Hypoxia | NA | NA | 1 | NA |
| Hypotension | 3 | 2 | NA | NA |
| Fever | 1 | NA | 2 | NA |
| Catheter-related infection | NA | 1 | NA | NA |
| Arthralgia | 2 | NA | NA | NA |
| Sinus tachycardia | 1 | NA | NA | NA |
| Rigors/chills | 1 | NA | NA | NA |
| Weight loss | 1 | NA | NA | NA |