Toxicities observed in patients with CLL treated with depsipeptide
Toxicity . | Grade 1, no. . | Grade 2, no. . | Grade 3, no. . | Grade 4, no. . |
|---|---|---|---|---|
| Anorexia | 6 | 2 | 1 | 0 |
| Fatigue | 3 | 7 | 0 | 0 |
| Nausea | 3 | 6 | 0 | 0 |
| Vomiting | 1 | 5 | 0 | 1 |
| Myalgias | 5 | 2 | 0 | 0 |
| Headache | 4 | 1 | 0 | 0 |
| Diarrhea | 4 | 2 | 0 | 0 |
| Insomnia | 2 | 0 | 0 | 0 |
| Mood alteration | 0 | 2 | 0 | 0 |
| Taste loss | 4 | 0 | 0 | 0 |
| Dyspepsia | 1 | 1 | 0 | 0 |
| Stomatitis | 1 | 4 | 0 | 0 |
| Abdominal pain | 2 | 0 | 0 | 0 |
| Dyspnea | 0 | 3 | 0 | 0 |
| Cough | 0 | 2 | 0 | 0 |
| Diaphoresis | 3 | 1 | 0 | 0 |
| Rash | 0 | 1 | 0 | 0 |
| Edema | 2 | 1 | 0 | 0 |
| Chest pain | 1 | 0 | 0 | 0 |
| Hyponatremia | 0 | 0 | 2 | 0 |
| Dizziness | 1 | 1 | 0 | 0 |
| Ataxia | 0 | 1 | 0 | 0 |
| Infection | 1 | 1 | 1 | 0 |
| Tumor lysis | 0 | 0 | 0 | 0 |
| Hyperglycemia | 0 | 0 | 0 | 0 |
| Constipation | 5 | 1 | 0 | 0 |
| Arthralgia | 1 | 1 | 0 | 0 |
| Catheter-related infection | 1 | 0 | 0 | 0 |
| Sinus tachycardia | 1 | 0 | 0 | 0 |
| Epistaxis | 1 | 0 | 0 | 0 |
| Neutropenia | 2 | 1 | 1 | 6 |
| Anemia | 6 | 2 | 0 | 0 |
| Thrombocytopenia | 0 | 2 | 6 | 2 |
Toxicity . | Grade 1, no. . | Grade 2, no. . | Grade 3, no. . | Grade 4, no. . |
|---|---|---|---|---|
| Anorexia | 6 | 2 | 1 | 0 |
| Fatigue | 3 | 7 | 0 | 0 |
| Nausea | 3 | 6 | 0 | 0 |
| Vomiting | 1 | 5 | 0 | 1 |
| Myalgias | 5 | 2 | 0 | 0 |
| Headache | 4 | 1 | 0 | 0 |
| Diarrhea | 4 | 2 | 0 | 0 |
| Insomnia | 2 | 0 | 0 | 0 |
| Mood alteration | 0 | 2 | 0 | 0 |
| Taste loss | 4 | 0 | 0 | 0 |
| Dyspepsia | 1 | 1 | 0 | 0 |
| Stomatitis | 1 | 4 | 0 | 0 |
| Abdominal pain | 2 | 0 | 0 | 0 |
| Dyspnea | 0 | 3 | 0 | 0 |
| Cough | 0 | 2 | 0 | 0 |
| Diaphoresis | 3 | 1 | 0 | 0 |
| Rash | 0 | 1 | 0 | 0 |
| Edema | 2 | 1 | 0 | 0 |
| Chest pain | 1 | 0 | 0 | 0 |
| Hyponatremia | 0 | 0 | 2 | 0 |
| Dizziness | 1 | 1 | 0 | 0 |
| Ataxia | 0 | 1 | 0 | 0 |
| Infection | 1 | 1 | 1 | 0 |
| Tumor lysis | 0 | 0 | 0 | 0 |
| Hyperglycemia | 0 | 0 | 0 | 0 |
| Constipation | 5 | 1 | 0 | 0 |
| Arthralgia | 1 | 1 | 0 | 0 |
| Catheter-related infection | 1 | 0 | 0 | 0 |
| Sinus tachycardia | 1 | 0 | 0 | 0 |
| Epistaxis | 1 | 0 | 0 | 0 |
| Neutropenia | 2 | 1 | 1 | 6 |
| Anemia | 6 | 2 | 0 | 0 |
| Thrombocytopenia | 0 | 2 | 6 | 2 |