Distribution of MTHFR 677 genotype in 487 pediatric NHL patients and 379 controls, and its association with risk of disease in all patients from trial NHL-BFM 95 and by selected histologic subgroups
MTHFR . | No. of subjects (%) . | Odds ratio (CI, 95%) . | P . |
|---|---|---|---|
| Controls, n = 379 | |||
| 677C C | 184 (48.5) | NA | NA |
| 677C T | 152 (40.1) | NA | NA |
| 677T T | 43 (11.3) | NA | NA |
| All NHL patients, n = 487 | |||
| 677C C | 207 (42.5) | 1.00 (referent) | NA |
| 677C T | 216 (44.4) | 1.26 (0.95-1.68) | .11 |
| 677T T | 64 (13.1) | 1.32 (0.86-2.04) | .21 |
| Lymphoblastic lymphoma, n = 100 (20.5%) | |||
| 677C C | 36 (36.0) | 1.00 (referent) | NA |
| 677C T | 46 (46.0) | 1.55 (0.95-2.51) | .08 |
| 677T T | 18 (18.0) | 2.14 (1.11-4.12) | .02 |
| Burkitt lymphoma, n = 220 (45.2%) | |||
| 677C C | 92 (41.8) | 1.00 (referent) | NA |
| 677C T | 96 (43.6) | 1.26 (0.88-1.81) | .20 |
| 677T T | 32 (14.5) | 1.49 (0.88-2.51) | .14 |
| Diffuse large B-cell lymphoma, n = 65 (13.3%) | |||
| 677C C | 31 (47.7) | 1.00 (referent) | NA |
| 677C T | 28 (43.1) | 1.09 (0.63-1.90) | .75 |
| 677T T | 6 (9.2) | 0.83 (0.33-2.11) | .69 |
| Anaplastic large cell lymphoma, n = 67 (13.8%) | |||
| 677C C | 32 (47.8) | 1.00 (referent) | NA |
| 677C T | 29 (43.3) | 1.10 (0.64-1.89) | .74 |
| 677T T | 6 (9.0) | 0.80 (0.32-2.04) | .64 |
MTHFR . | No. of subjects (%) . | Odds ratio (CI, 95%) . | P . |
|---|---|---|---|
| Controls, n = 379 | |||
| 677C C | 184 (48.5) | NA | NA |
| 677C T | 152 (40.1) | NA | NA |
| 677T T | 43 (11.3) | NA | NA |
| All NHL patients, n = 487 | |||
| 677C C | 207 (42.5) | 1.00 (referent) | NA |
| 677C T | 216 (44.4) | 1.26 (0.95-1.68) | .11 |
| 677T T | 64 (13.1) | 1.32 (0.86-2.04) | .21 |
| Lymphoblastic lymphoma, n = 100 (20.5%) | |||
| 677C C | 36 (36.0) | 1.00 (referent) | NA |
| 677C T | 46 (46.0) | 1.55 (0.95-2.51) | .08 |
| 677T T | 18 (18.0) | 2.14 (1.11-4.12) | .02 |
| Burkitt lymphoma, n = 220 (45.2%) | |||
| 677C C | 92 (41.8) | 1.00 (referent) | NA |
| 677C T | 96 (43.6) | 1.26 (0.88-1.81) | .20 |
| 677T T | 32 (14.5) | 1.49 (0.88-2.51) | .14 |
| Diffuse large B-cell lymphoma, n = 65 (13.3%) | |||
| 677C C | 31 (47.7) | 1.00 (referent) | NA |
| 677C T | 28 (43.1) | 1.09 (0.63-1.90) | .75 |
| 677T T | 6 (9.2) | 0.83 (0.33-2.11) | .69 |
| Anaplastic large cell lymphoma, n = 67 (13.8%) | |||
| 677C C | 32 (47.8) | 1.00 (referent) | NA |
| 677C T | 29 (43.3) | 1.10 (0.64-1.89) | .74 |
| 677T T | 6 (9.0) | 0.80 (0.32-2.04) | .64 |
There were 35 patients (7.2%) not included in the stratified analyses who were diagnosed with peripheral T-cell lymphoma (n = 7) or other NHL entities (n = 28). Odds ratios compare the ratio of genotypes in patients in each category to controls.
CI indicates confidence interval; NA, not applicable.