Table 2.

Information on primary patient samples examined

Patient no.
FLT3 expression
Cytogenetics/ALL subtype
FLT3 genotype
Child/infant
J-1   High   MLL   WT   Infant  
J-2   High   MLL   WT   Infant  
J-3   High   MLL   D835E   Infant  
J-4   High   MLL   WT   Infant  
J-5   High   MLL   WT   Infant  
J-6   High   MLL   WT   Child  
J-7   High   MLL   WT   Child  
J-8   High   MLL   WT   Child  
J-9   High   MLL   WT   Child  
J-10   High   MLL   WT   Child  
J-11   Borderline   Hyper > 50   WT   Infant  
J-12   High   Hyper > 50   WT   Child  
J-13   High   Hyper > 50   D835E   Child  
J-14   High   Hyper > 50   ITD   Child  
J-15   High   Hyper > 50   WT   Child  
J-16   High   Hypo   WT   Child  
J-17   High   Pseudo   WT   Child  
J-18   High   Pseudo   JM del/ins   Child  
J-19   High   Hyper 47-50   WT   Infant  
J-20   High   Normal   WT   Child  
J-21   High   Normal   WT   Child  
J-22   Low  E2A-PBX1  WT   Child  
J-23   Low  E2A-PBX1  WT   Child  
J-24   Low  TEL-AML1  WT   Child  
J-25   Low  TEL-AML1  WT   Child  
J-26*  Low   T-ALL   WT   Child  
J-27   Low   T-ALL   WT   Child  
J-28   Low  BCR-ABL  WT   Child  
J-29   Low  BCR-ABL  WT   Child  
J-30   Low   Pseudo   WT   Child  
H-1   High   MLL   WT   Infant  
H-2   High   Inv(19)   WT   Child  
H-3   High   Hyper > 50   WT   Child  
H-4   ND   Normal   WT   Infant  
H-5   Low   T-ALL   WT   Child  
H-6   Low   T-ALL   WT   Child  
H-7   Low   Normal   WT   Child  
H-8   Low  MYC-IGH  WT   Child  
H-9   Low   Normal   WT   Child  
H-10
 		 Low
 		 Normal
 		 WT
 		 Child
 
Patient no.
FLT3 expression
Cytogenetics/ALL subtype
FLT3 genotype
Child/infant
J-1   High   MLL   WT   Infant  
J-2   High   MLL   WT   Infant  
J-3   High   MLL   D835E   Infant  
J-4   High   MLL   WT   Infant  
J-5   High   MLL   WT   Infant  
J-6   High   MLL   WT   Child  
J-7   High   MLL   WT   Child  
J-8   High   MLL   WT   Child  
J-9   High   MLL   WT   Child  
J-10   High   MLL   WT   Child  
J-11   Borderline   Hyper > 50   WT   Infant  
J-12   High   Hyper > 50   WT   Child  
J-13   High   Hyper > 50   D835E   Child  
J-14   High   Hyper > 50   ITD   Child  
J-15   High   Hyper > 50   WT   Child  
J-16   High   Hypo   WT   Child  
J-17   High   Pseudo   WT   Child  
J-18   High   Pseudo   JM del/ins   Child  
J-19   High   Hyper 47-50   WT   Infant  
J-20   High   Normal   WT   Child  
J-21   High   Normal   WT   Child  
J-22   Low  E2A-PBX1  WT   Child  
J-23   Low  E2A-PBX1  WT   Child  
J-24   Low  TEL-AML1  WT   Child  
J-25   Low  TEL-AML1  WT   Child  
J-26*  Low   T-ALL   WT   Child  
J-27   Low   T-ALL   WT   Child  
J-28   Low  BCR-ABL  WT   Child  
J-29   Low  BCR-ABL  WT   Child  
J-30   Low   Pseudo   WT   Child  
H-1   High   MLL   WT   Infant  
H-2   High   Inv(19)   WT   Child  
H-3   High   Hyper > 50   WT   Child  
H-4   ND   Normal   WT   Infant  
H-5   Low   T-ALL   WT   Child  
H-6   Low   T-ALL   WT   Child  
H-7   Low   Normal   WT   Child  
H-8   Low  MYC-IGH  WT   Child  
H-9   Low   Normal   WT   Child  
H-10
 		 Low
 		 Normal
 		 WT
 		 Child
 

J indicates St Jude patient; MLL, rearranged MLL gene; WT, wild type FLT3; D835E, substitution of glutamate for aspartate at position 835 of FLT3; Hyper > 50, high hyperdiploid (> 50 chromosomes); ITD, FLT3 internal tandem duplication; Hypo, hypodiploid; Pseudo, pseudodiploid; JM del/ins, FLT3 juxtamembrane region deletion/insertion; Hyper 47-50, hyperdiploid (47-50 chromosomes); E2A-PBX1, t(1;19); TEL-AML1, t(12;21); T-ALL, T-cell lineage ALL; BCR-ABL, t(9;22); H, Johns Hopkins patient; ND, not determined; and MYC-IGH, t(8;14).

*

Sample not evaluable

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