Number of days between beginning of 2 subsequent courses in randomized patients (MTX intravenous infusion as given)
. | R1 . | . | . | . | R2 . | . | . | . | R3/R4 . | . | . | . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | MTX-4h . | . | MTX-24h . | . | MTX-4h . | . | MTX-24h . | . | MTX-4h . | . | MTX-24h . | . | |||||||||
. | Median d (range) . | No. patients . | Median d (range) . | No. patients . | Median d (range) . | No. patients . | Median d (range) . | No. patients . | Median d (range) . | No. patients . | Median d (range) . | No. patients . | |||||||||
| Interval course* | |||||||||||||||||||||
| 1 to 2 | 22 (19-34) | 20 | 22 (18-26) | 20 | 22 (15-49) | 86 | 22 (14-31) | 95 | 21 (16-32) | 58 | 21 (15-41) | 69 | |||||||||
| 2 to 3 | NA | NA | NA | NA | 22 (15-42) | 86 | 22 (17-43) | 95 | 21 (14-29) | 57 | 22 (17-51) | 68 | |||||||||
| 3 to 4 | NA | NA | NA | NA | 23 (16-43) | 84 | 23 (18-36) | 94 | 22 (16-38) | 56 | 22 (17-36) | 68 | |||||||||
| 4 to 5 | NA | NA | NA | NA | NA | NA | NA | NA | 23 (15-43) | 55 | 22 (18-43) | 64 | |||||||||
| 5 to 6 | NA | NA | NA | NA | NA | NA | NA | NA | 22 (17-43) | 27† | 23 (18-41) | 37† | |||||||||
. | R1 . | . | . | . | R2 . | . | . | . | R3/R4 . | . | . | . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | MTX-4h . | . | MTX-24h . | . | MTX-4h . | . | MTX-24h . | . | MTX-4h . | . | MTX-24h . | . | |||||||||
. | Median d (range) . | No. patients . | Median d (range) . | No. patients . | Median d (range) . | No. patients . | Median d (range) . | No. patients . | Median d (range) . | No. patients . | Median d (range) . | No. patients . | |||||||||
| Interval course* | |||||||||||||||||||||
| 1 to 2 | 22 (19-34) | 20 | 22 (18-26) | 20 | 22 (15-49) | 86 | 22 (14-31) | 95 | 21 (16-32) | 58 | 21 (15-41) | 69 | |||||||||
| 2 to 3 | NA | NA | NA | NA | 22 (15-42) | 86 | 22 (17-43) | 95 | 21 (14-29) | 57 | 22 (17-51) | 68 | |||||||||
| 3 to 4 | NA | NA | NA | NA | 23 (16-43) | 84 | 23 (18-36) | 94 | 22 (16-38) | 56 | 22 (17-36) | 68 | |||||||||
| 4 to 5 | NA | NA | NA | NA | NA | NA | NA | NA | 23 (15-43) | 55 | 22 (18-43) | 64 | |||||||||
| 5 to 6 | NA | NA | NA | NA | NA | NA | NA | NA | 22 (17-43) | 27† | 23 (18-41) | 37† | |||||||||