Table 7. Serum methotrexate... | American Society of Hematology

Table 7.

Serum methotrexate concentrations of randomized patients

	R1 + R2			R3 + R4
	1 g/m² MTX			5 g/m² MTX
	4 h^*	24 h^*	4 h^*	24 h^*
No. MTX courses given	305	318	199	235
MTX serum concentration at hour 24,† μM, median (range)	0.32 (0.1-75.9)	8.17 (0.1-107.0)	0.88 (0.1-31.0)	46.40 (0.3-344.9)
MTX serum concentration at hour 42 † μM, median (range)	0.09 (0-2.6)	0.18 (0-1.0)	0.18 (0-13.0)	0.43 (0-6.5)
MTX serum concentration at hour 48,† μM, median (range)	0.06 (0-1.2)	0.1 (0-0.7)	0.13 (0-4.9)	0.24 (0-5.0)

	R1 + R2			R3 + R4
	1 g/m² MTX			5 g/m² MTX
	4 h^*	24 h^*	4 h^*	24 h^*
No. MTX courses given	305	318	199	235
MTX serum concentration at hour 24,† μM, median (range)	0.32 (0.1-75.9)	8.17 (0.1-107.0)	0.88 (0.1-31.0)	46.40 (0.3-344.9)
MTX serum concentration at hour 42 † μM, median (range)	0.09 (0-2.6)	0.18 (0-1.0)	0.18 (0-13.0)	0.43 (0-6.5)
MTX serum concentration at hour 48,† μM, median (range)	0.06 (0-1.2)	0.1 (0-0.7)	0.13 (0-4.9)	0.24 (0-5.0)

Indicates the number of hours over which the infusion was given.

After the beginning of MTX intravenous infusion.