Table 1. Therapy courses . . Day . . . .... | American Society of Hematology

Table 1.

Therapy courses

		Day
Drug	Dose	1	2	3	4	5
Prephase V
Dexamethasone orally/IV	mg/m²^¶	5	5	10	10	10
Cyclophosphamide IV 1 h	200 mg/m²	x	x
Methotrexate^* IT	12 mg	x
Cytarabine^* IT	30 mg	x
Prednisolone^* IT	10 mg	x
Course A
Dexamethasone orally/IV	10 mg/m²^¶	x	x	x	x	x
Vincristine IV	1.5 mg/m²∥	x
Ifosfamide IV 1 h	800 mg/m²	x	x	x	x	x
Cytarabine IV 1 h	150 mg/m²				x - x^**	x - x^**
Etoposide IV 1 h	100 mg/m²				x	x
Methotrexate IV†	1 g/m²	x
Methotrexate^* IT	12 mg	x
Cytarabine^* IT	30 mg	x
Prednisolone^* IT	10 mg	x
Course B
Dexamethasone orally/IV	10 mg/m²^¶	x	x	x	x	x
Vincristine IV	1.5 mg/m²∥	x
Cyclophosphamide IV 1 h	200 mg/m²	x	x	x	x	x
Doxorubicin IV 1 h	25 mg/m²				x	x
Methotrexate IV†	1 g/m²	x
Methotrexate^* IT	12 mg	x
Cytarabine^* IT	30 mg	x
Prednisolone^* IT	10 mg	x
Courses AA‡§ and BB‡§
Methotrexate IV†	5 g/m²	x
Methotrexate^* IT	6 mg	x				x
Cytarabine^* IT	15 mg	x				x
Prednisolone^* IT	5 mg	x				x
Course CC‡
Dexamethasone orally/IV	20 mg/m²^¶	x	x	x	x	x
Vindesine IV	3 mg/m²††	x
Cytarabine IV 3 h	3 g/m²	x - x^**	x - x^**
Etoposide IV 2 h	100 mg/m²			x - x^**	x - x^**	x^**
Methotrexate^* IT	12 mg					x
Cytarabine^* IT	30 mg					x
Prednisolone^* IT	10 mg					x

		Day
Drug	Dose	1	2	3	4	5
Prephase V
Dexamethasone orally/IV	mg/m²^¶	5	5	10	10	10
Cyclophosphamide IV 1 h	200 mg/m²	x	x
Methotrexate^* IT	12 mg	x
Cytarabine^* IT	30 mg	x
Prednisolone^* IT	10 mg	x
Course A
Dexamethasone orally/IV	10 mg/m²^¶	x	x	x	x	x
Vincristine IV	1.5 mg/m²∥	x
Ifosfamide IV 1 h	800 mg/m²	x	x	x	x	x
Cytarabine IV 1 h	150 mg/m²				x - x^**	x - x^**
Etoposide IV 1 h	100 mg/m²				x	x
Methotrexate IV†	1 g/m²	x
Methotrexate^* IT	12 mg	x
Cytarabine^* IT	30 mg	x
Prednisolone^* IT	10 mg	x
Course B
Dexamethasone orally/IV	10 mg/m²^¶	x	x	x	x	x
Vincristine IV	1.5 mg/m²∥	x
Cyclophosphamide IV 1 h	200 mg/m²	x	x	x	x	x
Doxorubicin IV 1 h	25 mg/m²				x	x
Methotrexate IV†	1 g/m²	x
Methotrexate^* IT	12 mg	x
Cytarabine^* IT	30 mg	x
Prednisolone^* IT	10 mg	x
Courses AA‡§ and BB‡§
Methotrexate IV†	5 g/m²	x
Methotrexate^* IT	6 mg	x				x
Cytarabine^* IT	15 mg	x				x
Prednisolone^* IT	5 mg	x				x
Course CC‡
Dexamethasone orally/IV	20 mg/m²^¶	x	x	x	x	x
Vindesine IV	3 mg/m²††	x
Cytarabine IV 3 h	3 g/m²	x - x^**	x - x^**
Etoposide IV 2 h	100 mg/m²			x - x^**	x - x^**	x^**
Methotrexate^* IT	12 mg					x
Cytarabine^* IT	30 mg					x
Prednisolone^* IT	10 mg					x

IV indicates intravenously; h, hour; IT, intrathecally.

Doses were adjusted for children younger than 3 years. In courses A, B, AA, and BB, intrathecal therapy was administered 24 hours after beginning of MTX intravenous infusion.

†

Patients were randomized to receive MTX as continuous intravenous infusion either over 24 hours or over 4 hours. In the 24-hour arm, 10% of the MTX dose was given within 0.5 hours, 90% of dose intravenously over 23.5 hours. Racemic folinic acid (leucovorin) intravenously 15 mg/m² at hours 42, 48, and 54 after beginning of MTX. In courses AA and BB, the dose of leucovorin at hour 42 was 30 mg/m² intravenously. Adjustment of leucovorin dose in case of impaired MTX excretion as previously described.⁴

‡

For CNS-positive patients, chemotherapy was applied intraventricularly as described in “Chemotherapy.”

Courses AA and BB are the same as A and B, respectively, with the exceptions listed.

Subdivided in 3 doses.

∥

Maximum dose was 2 mg; vincristine was not given in patients of branch R1.

Doses are 12 hours apart.

††

Maximum dose was 5 mg.

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