Adjusted mean doses of warfarin prescribed according to different genotype/haplotype
. | Adjusted mean, mg . | 95% CI . | Significance . |
|---|---|---|---|
| VKORC1 | |||
| 1173CC | 6.2 | 5.0-7.3 | Ref |
| 1173CT | 4.8 | 3.8-5.9 | .002 |
| 1173TT | 3.5 | 2.2-4.8 | < .001 |
| .018* | |||
| CYP2C9 | |||
| CYP2C9*1 | 6.0 | 5.3-6.7 | Ref |
| CYP2C9*2 | 4.7 | 3.8-5.5 | .002 |
| CYP2C9*3 | 3.8 | 2.7-4.8 | < .001 |
| CYP2C9*2 + CYP2C9*3 | 4.9 | 1.6-8.3 | NS |
. | Adjusted mean, mg . | 95% CI . | Significance . |
|---|---|---|---|
| VKORC1 | |||
| 1173CC | 6.2 | 5.0-7.3 | Ref |
| 1173CT | 4.8 | 3.8-5.9 | .002 |
| 1173TT | 3.5 | 2.2-4.8 | < .001 |
| .018* | |||
| CYP2C9 | |||
| CYP2C9*1 | 6.0 | 5.3-6.7 | Ref |
| CYP2C9*2 | 4.7 | 3.8-5.5 | .002 |
| CYP2C9*3 | 3.8 | 2.7-4.8 | < .001 |
| CYP2C9*2 + CYP2C9*3 | 4.9 | 1.6-8.3 | NS |
Adjusted mean is calculated as the mean daily dose of warfarin taking into account other variables.
CI indicates confidence intervals; Ref, reference group, NS, not significant.
Versus CT genotype.