Cellular pharmacokinetics of ara-CTP and clofarabine triphosphate
. | . | . | Ara-CTP, μM (h) . | . | . | . | . | |
|---|---|---|---|---|---|---|---|---|
| Patient no. . | Diagnosis . | Clofarabine, mg/m2 per day . | Day 1 . | Day 2 . | Ara-CTP, ratio of day 2 to day 1 . | CTP, μM . | Response . | |
| 1 | AML | 15 | 374 (3) | 315 (3) | 0.8 | BLQ | Fail | |
| 6 | ALL | 22.5 | 337 (2) | 434 (2) | 1.3 | 13 | Fail | |
| 7 | AML | 30 | 159 (2) | 328 (2) | 2.1 | 19 | CRp | |
| 8 | ALL | 30 | 199 (2) | 191 (2) | 1.0 | 19 | Fail | |
| 9 | AML | 30 | 118 (2) | 101 (2) | 0.9 | BLQ | Fail | |
| 16 | CML MBP | 40 | 108 (1) | 142 (1) | 1.3 | 9 | Fail | |
| 17 | AML | 40 | 105 (1) | 152 (1) | 1.5 | 4 | CR | |
| 26 | RAEB-T | 40 | 168 (1) | 240 (1) | 1.4 | 10 | Fail | |
. | . | . | Ara-CTP, μM (h) . | . | . | . | . | |
|---|---|---|---|---|---|---|---|---|
| Patient no. . | Diagnosis . | Clofarabine, mg/m2 per day . | Day 1 . | Day 2 . | Ara-CTP, ratio of day 2 to day 1 . | CTP, μM . | Response . | |
| 1 | AML | 15 | 374 (3) | 315 (3) | 0.8 | BLQ | Fail | |
| 6 | ALL | 22.5 | 337 (2) | 434 (2) | 1.3 | 13 | Fail | |
| 7 | AML | 30 | 159 (2) | 328 (2) | 2.1 | 19 | CRp | |
| 8 | ALL | 30 | 199 (2) | 191 (2) | 1.0 | 19 | Fail | |
| 9 | AML | 30 | 118 (2) | 101 (2) | 0.9 | BLQ | Fail | |
| 16 | CML MBP | 40 | 108 (1) | 142 (1) | 1.3 | 9 | Fail | |
| 17 | AML | 40 | 105 (1) | 152 (1) | 1.5 | 4 | CR | |
| 26 | RAEB-T | 40 | 168 (1) | 240 (1) | 1.4 | 10 | Fail | |
BLQ indicates below limit of quantitation; CTP, clofarabine triphosphate; CML MBP, CML in myeloid blast phase.