Table 7.

Effect of ara-C infusion on clofarabine plasma pharmacokinetics

Clofarabine, μM; end of infusion
Clofarabine, μM; 6-h sample
Patient no.
Clofarabine, mg/m2 per d
Day 2
Day 6
Day 2
Day 6
1   15   0.61   0.58   0.06   ND  
5   22.5   0.89   0.86   0.14   0.21  
6   22.5   0.90   1.28   0.10   0.21  
7   30   1.34   2.01   0.31   0.31  
8   30   ND   1.39   0.13†   0.17* 
9   30   1.33   1.35   0.14   0.13  
10   40   2.03   1.32   0.08   0.18  
11   40   1.28   2.55   0.23   0.20  
12
 		 40
 		 2.12
 		 1.34
 		 0.11
 		 0.10
 
Clofarabine, μM; end of infusion
Clofarabine, μM; 6-h sample
Patient no.
Clofarabine, mg/m2 per d
Day 2
Day 6
Day 2
Day 6
1   15   0.61   0.58   0.06   ND  
5   22.5   0.89   0.86   0.14   0.21  
6   22.5   0.90   1.28   0.10   0.21  
7   30   1.34   2.01   0.31   0.31  
8   30   ND   1.39   0.13†   0.17* 
9   30   1.33   1.35   0.14   0.13  
10   40   2.03   1.32   0.08   0.18  
11   40   1.28   2.55   0.23   0.20  
12
 		 40
 		 2.12
 		 1.34
 		 0.11
 		 0.10
 

ND indicates not determined.

*

A 5-hour sample was used instead of a 6-hour sample.

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