Individual and mean plasma clofarabine pharmacokinetic parameters
Patient no. . | Clofarabine, mg/m2 . | Clearance, L/h/m2 . | Volume of central compartment, L/m2 . | Volume of distribution at steady-state, L/m2 . | α half-life, h . | β half-life, h . | Cmax, μM . |
|---|---|---|---|---|---|---|---|
| 1 | 15 | 12.1 | 51.3 | 294.4 | 0.41 | 18.6 | 0.48 |
| 5 | 22.5 | 17.4 | 45.7 | 128.7 | 0.19 | 14.1 | 0.89 |
| 6 | 22.5 | 12.7 | 44.4 | 209.1 | 0.29 | 5.8 | 1.05 |
| 7 | 30 | 11.3 | 15.6 | 90.7 | 0.37 | 6.9 | 2.65 |
| 8 | 30 | 16.2 | 10.9 | 90.8 | 0.19 | 7.4 | 2.95 |
| 9 | 30 | 22.1 | 45.3 | 126.5 | 0.17 | 5.1 | 1.29 |
| 10 | 40 | 27.0 | 43.1 | 109.5 | 0.15 | 5.1 | 1.96 |
| 11 | 40 | 20.3 | 39.1 | 110.4 | 0.21 | 3.4 | 2.08 |
| 12 | 40 | 33.1 | 41.4 | 122.8 | 0.19 | 5.3 | 1.52 |
| Mean | NA | 19.1 | 37.4 | 142.5 | 0.24 | 6.7 | ND |
| SD | NA | 7.3 | 14.1 | 66.7 | 0.09 | 3.1 | ND |
Patient no. . | Clofarabine, mg/m2 . | Clearance, L/h/m2 . | Volume of central compartment, L/m2 . | Volume of distribution at steady-state, L/m2 . | α half-life, h . | β half-life, h . | Cmax, μM . |
|---|---|---|---|---|---|---|---|
| 1 | 15 | 12.1 | 51.3 | 294.4 | 0.41 | 18.6 | 0.48 |
| 5 | 22.5 | 17.4 | 45.7 | 128.7 | 0.19 | 14.1 | 0.89 |
| 6 | 22.5 | 12.7 | 44.4 | 209.1 | 0.29 | 5.8 | 1.05 |
| 7 | 30 | 11.3 | 15.6 | 90.7 | 0.37 | 6.9 | 2.65 |
| 8 | 30 | 16.2 | 10.9 | 90.8 | 0.19 | 7.4 | 2.95 |
| 9 | 30 | 22.1 | 45.3 | 126.5 | 0.17 | 5.1 | 1.29 |
| 10 | 40 | 27.0 | 43.1 | 109.5 | 0.15 | 5.1 | 1.96 |
| 11 | 40 | 20.3 | 39.1 | 110.4 | 0.21 | 3.4 | 2.08 |
| 12 | 40 | 33.1 | 41.4 | 122.8 | 0.19 | 5.3 | 1.52 |
| Mean | NA | 19.1 | 37.4 | 142.5 | 0.24 | 6.7 | ND |
| SD | NA | 7.3 | 14.1 | 66.7 | 0.09 | 3.1 | ND |
NA indicates not applicable; ND, not done.