Table 1. Clinical characteristics of... | American Society of Hematology

Table 1.

Clinical characteristics of misclassified patients with AL and patients with MM

Misclassified patients
29-gene subset	12-gene subset	Light chain isotype	BMPC, %	Hb, g/dL	Serum M-spike, g/dL	Lytic bone lesions
AL-1	NM	κ	3	10.4	Negative	Negative
AL-2	NM	λ	16	13.6	Negative	Negative
AL-3	AL-3	λ	25	11.2	Negative	Negative
AL-4	NM	λ	17	11.8	Negative	Negative
AL-5	NM	λ	9	7.7	1.9	Negative
ND	AL-6†	λ	13	10.7	1.0	Negative
ND	AL-7†	λ	11.6	13.2	2.2	Negative
MM-1	MM-1	λ	31	12.0	3.3	Negative
MM-2	MM-2	λ	30	11.3	Hypogamma^*	Negative
MM-3	NM	λ	38	9.5	1.2	Positive
MM-4	NM	λ	42	8.5	0.4	Positive
MM-5	NM	λ	25	9.7	0.4	Positive
NM	MM-6	κ	24	12	2.1	Negative
ND	MM-7†	κ	5.4	11	0.6	Positive

Misclassified patients
29-gene subset	12-gene subset	Light chain isotype	BMPC, %	Hb, g/dL	Serum M-spike, g/dL	Lytic bone lesions
AL-1	NM	κ	3	10.4	Negative	Negative
AL-2	NM	λ	16	13.6	Negative	Negative
AL-3	AL-3	λ	25	11.2	Negative	Negative
AL-4	NM	λ	17	11.8	Negative	Negative
AL-5	NM	λ	9	7.7	1.9	Negative
ND	AL-6†	λ	13	10.7	1.0	Negative
ND	AL-7†	λ	11.6	13.2	2.2	Negative
MM-1	MM-1	λ	31	12.0	3.3	Negative
MM-2	MM-2	λ	30	11.3	Hypogamma^*	Negative
MM-3	NM	λ	38	9.5	1.2	Positive
MM-4	NM	λ	42	8.5	0.4	Positive
MM-5	NM	λ	25	9.7	0.4	Positive
NM	MM-6	κ	24	12	2.1	Negative
ND	MM-7†	κ	5.4	11	0.6	Positive

The major clinical features of the misclassified patients with AL and patients with MM in Figure 1A and Figure 3 with respect to light chain isotype, bone marrow plasma cells (BMPCs), anemia, serum M-protein level, and lytic bone lesions are recorded.

NM indicates not misclassified; ND, not done.

Urine M-spike = 3.8 g/24 hours

†

Patients misclassified in independent validation analysis

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