Table 5.

Linkage scores for polymorphic markers in male mice associated with IgG response to human factor IX following AVC3FIX5 administration


LRS (LOD)

Chromosome

Marker
21.994 (LOD 4.8)   17   D 17Mit 62  
12.202 (LOD 2.6)   1   D 1Mit 100  
12.202 (LOD 2.6)   1   D 1Mit 264  
12.202 (LOD 2.6)   1   D 1Mit 199  
11.994 (LOD 2.6)   10   D 10Mit 179  
10.518 (LOD 2.3)   10   D 10Mit 74  
10.518 (LOD 2.3)   10   D 10Mit 237  
10.518 (LOD 2.3)   10   D 10Mit 267  
10.518 (LOD 2.3)
 
10
 
D 10Mit 180
 

LRS (LOD)

Chromosome

Marker
21.994 (LOD 4.8)   17   D 17Mit 62  
12.202 (LOD 2.6)   1   D 1Mit 100  
12.202 (LOD 2.6)   1   D 1Mit 264  
12.202 (LOD 2.6)   1   D 1Mit 199  
11.994 (LOD 2.6)   10   D 10Mit 179  
10.518 (LOD 2.3)   10   D 10Mit 74  
10.518 (LOD 2.3)   10   D 10Mit 237  
10.518 (LOD 2.3)   10   D 10Mit 267  
10.518 (LOD 2.3)
 
10
 
D 10Mit 180
 

The LOD is LOD score or log10 likelihood ratio statistic (LRS); LRS/4.61 = LOD score. LRS values of less than 17.89 were highly significant and values of more than 9.57 were highly suggestive of linkage by the marker regression analysis of the data in Figure 2 and Table 4 by the WebQTL software.

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