Viability of standard and treated platelets
. | . | Treated platelets . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
. | Standard . | C-LR . | F-LR × 1* . | F-LR × 2† . | F-LR/C-LR . | γ-F-LR/C-LR . | ||||
| No. of observations | 7 | 39 | 8 | 5 | 19 | 6 | ||||
| Platelet recovery | ||||||||||
| Treated, donor, % | 26 ± 16 | 49 ± 19 | 36 ± 15 | 54 ± 4 | 54 ± 19 | 36 ± 13 | ||||
| Control, autologous, % | 27 ± 8 | 56 ± 13 | 53 ± 10 | 51 ± 10 | 55 ± 9 | 42 ± 9 | ||||
| P | .70 | .04 | .02 | .44 | .70 | .68 | ||||
| Platelet survivals | ||||||||||
| Treated, donor, d | 3.0 ± 1.6 | 2.7 ± 1.6 | 4.0 ± 1.6 | 4.1 ± 1.9 | 3.0 ± 1.3 | 2.4 ± 0.9 | ||||
| Control, autologous, d | 3.3 ± 1.1 | 4.0 ± 1.1 | 3.9 ± 0.4 | 3.8 ± 0.4 | 4.0 ± 0.9 | 3.7 ± 1.0 | ||||
| P | .41 | < .01 | .87 | .74 | .01 | .03 | ||||
. | . | Treated platelets . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
. | Standard . | C-LR . | F-LR × 1* . | F-LR × 2† . | F-LR/C-LR . | γ-F-LR/C-LR . | ||||
| No. of observations | 7 | 39 | 8 | 5 | 19 | 6 | ||||
| Platelet recovery | ||||||||||
| Treated, donor, % | 26 ± 16 | 49 ± 19 | 36 ± 15 | 54 ± 4 | 54 ± 19 | 36 ± 13 | ||||
| Control, autologous, % | 27 ± 8 | 56 ± 13 | 53 ± 10 | 51 ± 10 | 55 ± 9 | 42 ± 9 | ||||
| P | .70 | .04 | .02 | .44 | .70 | .68 | ||||
| Platelet survivals | ||||||||||
| Treated, donor, d | 3.0 ± 1.6 | 2.7 ± 1.6 | 4.0 ± 1.6 | 4.1 ± 1.9 | 3.0 ± 1.3 | 2.4 ± 0.9 | ||||
| Control, autologous, d | 3.3 ± 1.1 | 4.0 ± 1.1 | 3.9 ± 0.4 | 3.8 ± 0.4 | 4.0 ± 0.9 | 3.7 ± 1.0 | ||||
| P | .41 | < .01 | .87 | .74 | .01 | .03 | ||||
Overall, autologous radiolabeled platelet recoveries and survivals in 73 normal dogs averaged 53% ± 12% and 4.1 ± 0.8 days, respectively (±1 SD). Data are given as average ±1 SD. P values are for paired t statistic comparing baseline autologous data for each dog compared with their first treated donor transfusion.
Treated indicates data from the first standard (if recipient was in the standard initial donor group) or treated donor platelet transfusion given to a recipient; and Control, data from the 2 baseline autologous platelet transfusions of the recipient animals.
Platelets were filtered once with a single filter
Platelets were filtered twice with 2 filters