Mean dN/dS ratios within the core-coding region for early and late time points for progressors (cases) versus nonprogressors (controls)
. | dN/dS ratio . | . | . | ||
|---|---|---|---|---|---|
| Time point . | Progressors (n = 10) . | Nonprogressors (n = 10) . | P for difference between progressors and nonprogressors . | ||
| Early dN/dS ratio | 0.15 (SE, 0.07) | 0.30 (SE, 0.10) | .05 | ||
| Late dN/dS ratio | 0.10 (SE, 0.03) | 0.16 (SE, 0.04) | .26 | ||
| Mean difference (early to late) in dN/dS ratio | - 0.05 (SE, 0.08) | - 0.13 (SE, 0.10) | .31 | ||
| P for difference over time | .54 | .21 | |||
. | dN/dS ratio . | . | . | ||
|---|---|---|---|---|---|
| Time point . | Progressors (n = 10) . | Nonprogressors (n = 10) . | P for difference between progressors and nonprogressors . | ||
| Early dN/dS ratio | 0.15 (SE, 0.07) | 0.30 (SE, 0.10) | .05 | ||
| Late dN/dS ratio | 0.10 (SE, 0.03) | 0.16 (SE, 0.04) | .26 | ||
| Mean difference (early to late) in dN/dS ratio | - 0.05 (SE, 0.08) | - 0.13 (SE, 0.10) | .31 | ||
| P for difference over time | .54 | .21 | |||
The numbers of dS and dN were determined using the Nei-Gojobori method with the Jukes-Cantor correction for multiple substitutions.22 The mean dN/dS ratio, a measure of selective pressure, was calculated for each patient.