Table 4.

Mean frequencies of unique core region nucleotide sequences for each patient subpopulation



Mean complexity
Time point
Progressors (n = 10)
Nonprogressors (n = 10)
Difference: progressor-nonprogressor*
Coinfected (n = 16)    
    Early   0.56 (SE, 0.11)   0.72 (SE, 0.06)   - 0.16  
    Late   0.61 (SE, 0.10)   0.73 (SE, 0.07)   - 0.12  
Monoinfected (n = 4)    
    Early   0.47 (SE, 0.20)   0.92 (SE, 0.08)   - 0.45  
    Late   0.89 (SE, 0.11)   0.83 (SE, 0.08)   0.06  
Total    
    Early   0.54 (SE, 0.09)   0.76 (SE, 0.05)   - 0.22  
    Late   0.67 (SE, 0.09)   0.75 (SE, 0.06)   - 0.08  
    Late-Early
 
0.13 (SE, 0.13)
 
- 0.01 (SE, 0.06)
 
0.14
 


Mean complexity
Time point
Progressors (n = 10)
Nonprogressors (n = 10)
Difference: progressor-nonprogressor*
Coinfected (n = 16)    
    Early   0.56 (SE, 0.11)   0.72 (SE, 0.06)   - 0.16  
    Late   0.61 (SE, 0.10)   0.73 (SE, 0.07)   - 0.12  
Monoinfected (n = 4)    
    Early   0.47 (SE, 0.20)   0.92 (SE, 0.08)   - 0.45  
    Late   0.89 (SE, 0.11)   0.83 (SE, 0.08)   0.06  
Total    
    Early   0.54 (SE, 0.09)   0.76 (SE, 0.05)   - 0.22  
    Late   0.67 (SE, 0.09)   0.75 (SE, 0.06)   - 0.08  
    Late-Early
 
0.13 (SE, 0.13)
 
- 0.01 (SE, 0.06)
 
0.14
 

Frequencies were determined by the proportion of unique nucleotide sequences to the number of clones assessed for each patient at early and late time points within the core-coding region.

*

P = NS for all comparisons.

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