Mean dN/dS ratio comparisons within the HVR1 for progressors (cases) and nonprogressors (controls)
. | dN/dS ratio . | . | . | ||
|---|---|---|---|---|---|
| Time point . | Progressors . | Nonprogressors . | P for difference between progressors and nonprogressors . | ||
| Early dN/dS ratio | 2.02 (SE, 0.70) | 0.98 (SE, 0.22) | .25 | ||
| Late dN/dS ratio | 0.62 (SE, 0.22) | 0.98 (SE, 0.39) | .52 | ||
| Mean difference (early to late) in dN/dS ratio | -1.40 (SE, 0.83) | -0.006 (SE, 0.55) | .31 | ||
| P for difference over time | .13 | .99 | |||
. | dN/dS ratio . | . | . | ||
|---|---|---|---|---|---|
| Time point . | Progressors . | Nonprogressors . | P for difference between progressors and nonprogressors . | ||
| Early dN/dS ratio | 2.02 (SE, 0.70) | 0.98 (SE, 0.22) | .25 | ||
| Late dN/dS ratio | 0.62 (SE, 0.22) | 0.98 (SE, 0.39) | .52 | ||
| Mean difference (early to late) in dN/dS ratio | -1.40 (SE, 0.83) | -0.006 (SE, 0.55) | .31 | ||
| P for difference over time | .13 | .99 | |||
The numbers of synonymous mutations (dS) and the numbers of nonsynonymous mutations (dN) were determined using the Nei-Gojobori method with the Jukes-Cantor correction for multiple substitutions.22 The mean dN/dS ratio, a measure of selective pressure, was calculated for each patient. One matched pair is excluded due to a shift in dominant subtype in the progressor. Progressors demonstrated an overall decrease in dN/dS ratio over time, whereas nonprogressors remain stable.