Mean frequencies of unique HVR1 nucleotide sequences for each patient subpopulation
. | Mean complexity . | . | . | ||
|---|---|---|---|---|---|
| Time point . | Progressors (n = 10) . | Nonprogressors (n = 10) . | Difference: progressor-nonprogressor . | ||
| Coinfected (n = 16) | |||||
| Early | 0.78 (SE, 0.02) | 0.54 (SE, 0.09) | 0.24 | ||
| Late | 0.65 (SE, 0.07) | 0.72 (SE, 0.07) | -0.07 | ||
| Monoinfected (n = 4) | |||||
| Early | 0.53 (SE, 0.03) | 0.81 (SE, 0.18) | -0.28 | ||
| Late | 0.48 (SE, 0.23) | 1.0 (SE, 0.0) | -0.52 | ||
| Total | |||||
| Early | 0.73 (SE, 0.04) | 0.59 (SE, 0.08) | 0.14 | ||
| Late | 0.61 (SE, 0.04) | 0.77 (SE, 0.07) | -0.16 | ||
| Late-early | -0.12 (SE, 0.07) | 0.18 (SE, 0.10) | -0.30* | ||
. | Mean complexity . | . | . | ||
|---|---|---|---|---|---|
| Time point . | Progressors (n = 10) . | Nonprogressors (n = 10) . | Difference: progressor-nonprogressor . | ||
| Coinfected (n = 16) | |||||
| Early | 0.78 (SE, 0.02) | 0.54 (SE, 0.09) | 0.24 | ||
| Late | 0.65 (SE, 0.07) | 0.72 (SE, 0.07) | -0.07 | ||
| Monoinfected (n = 4) | |||||
| Early | 0.53 (SE, 0.03) | 0.81 (SE, 0.18) | -0.28 | ||
| Late | 0.48 (SE, 0.23) | 1.0 (SE, 0.0) | -0.52 | ||
| Total | |||||
| Early | 0.73 (SE, 0.04) | 0.59 (SE, 0.08) | 0.14 | ||
| Late | 0.61 (SE, 0.04) | 0.77 (SE, 0.07) | -0.16 | ||
| Late-early | -0.12 (SE, 0.07) | 0.18 (SE, 0.10) | -0.30* | ||
Frequencies were determined by the proportion of unique nucleotide sequences to the number of clones assessed for each patient at early and late time points.
P = .01 for difference in unique nucleotide sequence frequencies between progressors and nonprogressors over time (generalized estimating equation model with binomial distribution and logit link).