Common integration sites and cooperative genes in NUP98-HOXA9/BXH2 leukemia
Chromosome locus, No. cM . | Candidate gene . | Distance from integrations . | Incidence in Tg/BXH2, % (n = 19) . | Incidence in BXH2, %* . |
|---|---|---|---|---|
| 11, 18.9 | Meis1 | Intragenic 3′ or 1 kb upstream | 47.4 | 15 |
| 15, 80.5 | Dnalc4 | Downstream 6-10 kb | 21.1 | None |
| 13, 48.9 | Con1 (BI526426) | Intron 1 | 15.8 | None |
| 1, 172.2 | Fcgr2b, Fcrl | Downstream 10-15 kb (Fcgr2b), upstream 15-20 kb (Fcrl) | 31.6 | None |
| 3, 121.7 | Con2 (AI854024) | Intron 1 | 15.8 | None |
Chromosome locus, No. cM . | Candidate gene . | Distance from integrations . | Incidence in Tg/BXH2, % (n = 19) . | Incidence in BXH2, %* . |
|---|---|---|---|---|
| 11, 18.9 | Meis1 | Intragenic 3′ or 1 kb upstream | 47.4 | 15 |
| 15, 80.5 | Dnalc4 | Downstream 6-10 kb | 21.1 | None |
| 13, 48.9 | Con1 (BI526426) | Intron 1 | 15.8 | None |
| 1, 172.2 | Fcgr2b, Fcrl | Downstream 10-15 kb (Fcgr2b), upstream 15-20 kb (Fcrl) | 31.6 | None |
| 3, 121.7 | Con2 (AI854024) | Intron 1 | 15.8 | None |
The incidence of integration in wild-type BXH2 was described previously (Moskow et al31 and Mouse Retroviral Tagged Cancer Gene Database (MRTCGD; http://genome2.ncifcrf.gov/RTCGD/)