Summary of exposure to rFIX
. | rFIX infusion type*† . | . | . | . | |||
|---|---|---|---|---|---|---|---|
. | On-demand treatment . | Prophylaxis‡ . | Surgery related§ . | Total . | |||
| No. of patients∥ | 54 | 42 | 23 | 56 | |||
| Total rFIX administered, IU/patient | |||||||
| Cumulative | 1 742 860 | 3 791 388 | 206 941 | 5 741 189 | |||
| Median (range) | 20 515 (690-240 293) | 83 825 (530-411 780) | 6130 (2000-31 580) | 91 620 (1260-483 140) | |||
| Dose/infusion, IU/kg | |||||||
| Median (range) | 62.70 (8.20-292.00) | 60.60 (9.70-230.40) | 70.00 (29.30-260.00) | 61.40 (8.20-292.00) | |||
| Mean ± SD | 75.58 ± 42.47 | 71.57 ± 36.89 | 89.87 ± 51.95 | 73.49 ± 39.47 | |||
| No. of infusions | |||||||
| Cumulative | 1505 | 3320 | 207 | 5032 | |||
| Median (range) | 19.00 (1-108) | 71.50 (1-212) | 6.00 (1-40) | 100.00 (1-239) | |||
| Mean ± SD | 27.87 ± 27.76 | 79.05 ± 68.74 | 9.00 ± 8.55 | 89.86 ± 74.04 | |||
| Duration of exposure, d | |||||||
| Cumulative | 1443 | 3311 | 117 | 4858 | |||
| Median (range) | 19.00 (1-107) | 71.50 (1-212) | 4.00 (1-20) | 93.50 (1-225) | |||
| Mean ± SD | 26.72 ± 26.41 | 78.83 ± 68.46 | 5.09 ± 3.96 | 86.75 ± 71.73 | |||
. | rFIX infusion type*† . | . | . | . | |||
|---|---|---|---|---|---|---|---|
. | On-demand treatment . | Prophylaxis‡ . | Surgery related§ . | Total . | |||
| No. of patients∥ | 54 | 42 | 23 | 56 | |||
| Total rFIX administered, IU/patient | |||||||
| Cumulative | 1 742 860 | 3 791 388 | 206 941 | 5 741 189 | |||
| Median (range) | 20 515 (690-240 293) | 83 825 (530-411 780) | 6130 (2000-31 580) | 91 620 (1260-483 140) | |||
| Dose/infusion, IU/kg | |||||||
| Median (range) | 62.70 (8.20-292.00) | 60.60 (9.70-230.40) | 70.00 (29.30-260.00) | 61.40 (8.20-292.00) | |||
| Mean ± SD | 75.58 ± 42.47 | 71.57 ± 36.89 | 89.87 ± 51.95 | 73.49 ± 39.47 | |||
| No. of infusions | |||||||
| Cumulative | 1505 | 3320 | 207 | 5032 | |||
| Median (range) | 19.00 (1-108) | 71.50 (1-212) | 6.00 (1-40) | 100.00 (1-239) | |||
| Mean ± SD | 27.87 ± 27.76 | 79.05 ± 68.74 | 9.00 ± 8.55 | 89.86 ± 74.04 | |||
| Duration of exposure, d | |||||||
| Cumulative | 1443 | 3311 | 117 | 4858 | |||
| Median (range) | 19.00 (1-107) | 71.50 (1-212) | 4.00 (1-20) | 93.50 (1-225) | |||
| Mean ± SD | 26.72 ± 26.41 | 78.83 ± 68.46 | 5.09 ± 3.96 | 86.75 ± 71.73 | |||
Excludes data for 5 patients due to inadequate source documentation at 3 study sites.
Excludes data for 2 patients from start of inhibitor development.
Includes primary and secondary (routine and intermittent) prophylaxis.
Excludes continuous infusions.
A patient may have received doses more than once a day for different reasons.