Mutated tyrosine kinases in human malignancies
Tyrosine kinase . | Malignancy . |
|---|---|
| BCR-ABL | CML1 |
| ALL2 | |
| AML3 | |
| TEL-ABL | ALL4 |
| AML5 | |
| Atypical CML6 | |
| PDGFR-β | CMML7-11 |
| AML12 | |
| TEL-Jak2 | Atypical CML13 |
| ALL14 | |
| ALK-1 | Anaplastic large cell lymphoma15 |
| RET | MEN216,17 |
| Papillary thyroid carcinoma18 | |
| EGFR | Glioblastoma multiforme19 |
| Nonsmall cell lung cancer20 | |
| TPR-TRK | Papillary thyroid cancer21 |
| TPR-MET | Gastric carcinoma22 |
| FLT3 | AML23 |
| MDS24 | |
| ALL23 | |
| PDGFR-α | HES25 |
| Systemic mast cell disease26 | |
| GIST27 | |
| c-KIT | AML28,29 |
| Mastocytosis/mast cell | |
| leukemia30,31 | |
| GIST32,33 | |
| c-met | Lung cancer34 |
| c-fms | AML, MDS35-37 |
| CMML38 | |
| FGFR | MPD/AML39 |
Tyrosine kinase . | Malignancy . |
|---|---|
| BCR-ABL | CML1 |
| ALL2 | |
| AML3 | |
| TEL-ABL | ALL4 |
| AML5 | |
| Atypical CML6 | |
| PDGFR-β | CMML7-11 |
| AML12 | |
| TEL-Jak2 | Atypical CML13 |
| ALL14 | |
| ALK-1 | Anaplastic large cell lymphoma15 |
| RET | MEN216,17 |
| Papillary thyroid carcinoma18 | |
| EGFR | Glioblastoma multiforme19 |
| Nonsmall cell lung cancer20 | |
| TPR-TRK | Papillary thyroid cancer21 |
| TPR-MET | Gastric carcinoma22 |
| FLT3 | AML23 |
| MDS24 | |
| ALL23 | |
| PDGFR-α | HES25 |
| Systemic mast cell disease26 | |
| GIST27 | |
| c-KIT | AML28,29 |
| Mastocytosis/mast cell | |
| leukemia30,31 | |
| GIST32,33 | |
| c-met | Lung cancer34 |
| c-fms | AML, MDS35-37 |
| CMML38 | |
| FGFR | MPD/AML39 |
MEN2 indicates multiple endocrine neoplasia 2 syndrome.