Injection schedule for groups of mice used to examine the effects of K-11706 and K-13144 on reversing inhibitions induced by IL-1β and TNFα
. | Injection . | . | Day . | . | . | . | . | . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Group . | Item . | Amount . | 0 . | 1 . | 2 . | 3 . | 4 . | 5 . | ||||||
A | PEG | 150 μL | x | x | x | x | x | x | ||||||
B | IL-1β | 1.67 × 104 U | x | x | x | x | ||||||||
C | TNF-α | 3.33 × 105 U | x | x | x | x | ||||||||
D | K-11706 | 3 mg/kg | x | x | x | x | x | x | ||||||
E | K-13144 | 3 mg/kg | x | x | x | x | x | x | ||||||
F | IL-1β | 1.67 × 104 U | x | x | x | x | ||||||||
K-11706 | 3 mg/kg | x | x | x | x | x | x | |||||||
G | IL-1β | 1.67 × 104 U | x | x | x | x | ||||||||
K-13144 | 3 mg/kg | x | x | x | x | x | x | |||||||
H | TNF-α | 3.33 × 105 U | x | x | x | x | ||||||||
K-11706 | 3 mg/kg | x | x | x | x | x | x | |||||||
I | TNF-α | 3.33 × 105 U | x | x | x | x | ||||||||
K-13144 | 3 mg/kg | x | x | x | x | x | x |
. | Injection . | . | Day . | . | . | . | . | . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Group . | Item . | Amount . | 0 . | 1 . | 2 . | 3 . | 4 . | 5 . | ||||||
A | PEG | 150 μL | x | x | x | x | x | x | ||||||
B | IL-1β | 1.67 × 104 U | x | x | x | x | ||||||||
C | TNF-α | 3.33 × 105 U | x | x | x | x | ||||||||
D | K-11706 | 3 mg/kg | x | x | x | x | x | x | ||||||
E | K-13144 | 3 mg/kg | x | x | x | x | x | x | ||||||
F | IL-1β | 1.67 × 104 U | x | x | x | x | ||||||||
K-11706 | 3 mg/kg | x | x | x | x | x | x | |||||||
G | IL-1β | 1.67 × 104 U | x | x | x | x | ||||||||
K-13144 | 3 mg/kg | x | x | x | x | x | x | |||||||
H | TNF-α | 3.33 × 105 U | x | x | x | x | ||||||||
K-11706 | 3 mg/kg | x | x | x | x | x | x | |||||||
I | TNF-α | 3.33 × 105 U | x | x | x | x | ||||||||
K-13144 | 3 mg/kg | x | x | x | x | x | x |