Thrombotic occlusion times of untreated HCII+/+ mice
Generation . | Heterozygous Ioci, % . | Occlusion times, s, mean ± SD . |
|---|---|---|
| F1 agouti | 100 | 24 ± 5 (n = 5)* |
| N6F1 | 3 | 39 ± 10 (n = 18)* |
| N10 or greater | 0.2 or lower | 59 ± 5 (n = 6) |
| Inbred C57BL/6 | 0 | 56 ± 7 (n = 9) |
Generation . | Heterozygous Ioci, % . | Occlusion times, s, mean ± SD . |
|---|---|---|
| F1 agouti | 100 | 24 ± 5 (n = 5)* |
| N6F1 | 3 | 39 ± 10 (n = 18)* |
| N10 or greater | 0.2 or lower | 59 ± 5 (n = 6) |
| Inbred C57BL/6 | 0 | 56 ± 7 (n = 9) |
F1 agouti mice were generated by mating C57BL/6 females with chimeric males derived from 129/SvJ embryonic stem cells.12 The F1 agouti mice were then backcrossed with inbred C57BL/6 mice. The approximate percentage of loci containing an allele from both strains (heterozygous loci) is indicated.
Data are from He et al.12