Summary of pharmacokinetic parameters of PKC412 and its metabolites
Parameters . | PKC412 . | CGP62221 . | CGP52421 . |
|---|---|---|---|
| Peak Ctrough, μg/mL | 5.39 ± 1.42 | 4.65 ± 1.03 | — |
| Time to Ctrough, day | 3 | 8 | — |
| Ctrough day 28, μg/mL | 1.72 ± 0.383 | 2.64 ± 0.512 | 13.1 ± 1.37 |
| Ctrough ss, μg/mL* | 1.35 ± 0.489 | 1.71 ± 0.413 | 13.8 ± 3.98 |
| Time to Ctrough ss, day | 28 | 28-37 | 28 |
Parameters . | PKC412 . | CGP62221 . | CGP52421 . |
|---|---|---|---|
| Peak Ctrough, μg/mL | 5.39 ± 1.42 | 4.65 ± 1.03 | — |
| Time to Ctrough, day | 3 | 8 | — |
| Ctrough day 28, μg/mL | 1.72 ± 0.383 | 2.64 ± 0.512 | 13.1 ± 1.37 |
| Ctrough ss, μg/mL* | 1.35 ± 0.489 | 1.71 ± 0.413 | 13.8 ± 3.98 |
| Time to Ctrough ss, day | 28 | 28-37 | 28 |
Values are mean ± SE.
Mean ± SD of concentrations after day 28.