Patient characteristics
Sex, M/F | 14/6 |
| Median age, y (range) | 62 (29-78) |
| Diagnosis | |
| Refractory AML | 7 |
| Relapsed AML | 10 |
| MDS | 1 |
| Median no. of prior regimens (range) | 4 (0-9) |
| Previously untreated | 3 (2 AML) |
| Karyotype | |
| Normal | 12 |
| t(6:9) | 1 |
| t(2:17) or t(2;12) | 2 |
| Inv(16) | 1 |
| 7q-/t(9;22) | 1 |
| Unevaluable | 3 |
| FLT3 mutation | |
| ITD | 18* |
| D835Y | 2 |
| Entry CBC | |
| Median WBC count, ×1000/μL (range) | 28 (0.9-12.0) |
| Median platelet count, ×1000/μL (range) | 30 (1-619) |
| Median ANC, ×1000/μL (range) | 1.0 (0-11.2) |
Sex, M/F | 14/6 |
| Median age, y (range) | 62 (29-78) |
| Diagnosis | |
| Refractory AML | 7 |
| Relapsed AML | 10 |
| MDS | 1 |
| Median no. of prior regimens (range) | 4 (0-9) |
| Previously untreated | 3 (2 AML) |
| Karyotype | |
| Normal | 12 |
| t(6:9) | 1 |
| t(2:17) or t(2;12) | 2 |
| Inv(16) | 1 |
| 7q-/t(9;22) | 1 |
| Unevaluable | 3 |
| FLT3 mutation | |
| ITD | 18* |
| D835Y | 2 |
| Entry CBC | |
| Median WBC count, ×1000/μL (range) | 28 (0.9-12.0) |
| Median platelet count, ×1000/μL (range) | 30 (1-619) |
| Median ANC, ×1000/μL (range) | 1.0 (0-11.2) |
ANC indicates absolute neutrophil count.
Median length, 48 base pairs (range, 21-289 base pairs; median percentage variant allele: 38% (range, 3%-100%).