Platelet counts and clotting times of mutant and control mice
. | C57BL/6 strain . | . | . | C57-129/SV (mixed) strain . | . | |||
|---|---|---|---|---|---|---|---|---|
| SLPI genotype | −/− | +/− | +/+ | +/− | +/+ | |||
| β1 tub genotype | +/+ | +/+ | +/+ | +/− | +/− | |||
| Platelet count, per μL (no. tested) | 1047 ± 255 (12) | 1130 ± 245 (19) | 1025 ± 160 (14) | 1128 ± 109* (8) | 1173 ± 131* (6) | |||
| Blood clotting time, s (no. tested) | 221 ± 43 (9) | ND | 226 ± 56 (10) | 240 ± 65 (8) | 275 ± 23 (6) | |||
| Plasma clotting time, s (no. tested) | 111 ± 12† (6) | ND | 77 ± 13† (6) | 107 ± 24 (8) | 110 ± 10 (6) | |||
. | C57BL/6 strain . | . | . | C57-129/SV (mixed) strain . | . | |||
|---|---|---|---|---|---|---|---|---|
| SLPI genotype | −/− | +/− | +/+ | +/− | +/+ | |||
| β1 tub genotype | +/+ | +/+ | +/+ | +/− | +/− | |||
| Platelet count, per μL (no. tested) | 1047 ± 255 (12) | 1130 ± 245 (19) | 1025 ± 160 (14) | 1128 ± 109* (8) | 1173 ± 131* (6) | |||
| Blood clotting time, s (no. tested) | 221 ± 43 (9) | ND | 226 ± 56 (10) | 240 ± 65 (8) | 275 ± 23 (6) | |||
| Plasma clotting time, s (no. tested) | 111 ± 12† (6) | ND | 77 ± 13† (6) | 107 ± 24 (8) | 110 ± 10 (6) | |||
ND indicates not determined.
The platelet count for β1 tubulin+/− mice in the mixed genetic background is higher than we reported previously,7 most likely owing to strain differences. Similarly, plasma clotting time is highly sensitive to mouse strain differences, and comparisons are valid only across the same genetic background.
P < .025 in an unpaired Mann-Whitney-Wilcoxon rank test.