Patient characteristics
. | . | p53 deletion . | . | . | |
|---|---|---|---|---|---|
| Characteristics . | Total, n = 105 . | Absent, n = 95 . | Present, n = 10 . | P . | |
| Sex, female/male | 42/62 | 40/54 | 2/8 | .17 | |
| Age, y (range) | 53 (31-71) | 54 (31-69) | 51 (40-71) | .84 | |
| β2-microglobulin level, mM (range) | 218.5 (118-4910) | 219 (118-4910) | 315 (201-430) | .67 | |
| CRP level, mg/L (range) | 3.5 (2.0-122.0) | 3.5 (2.5-122.0) | 2.0 (2.0-2.0) | .092 | |
| Calcium level, mM (range) | 2.4 (1.6-4.2) | 2.4 (1.6-4.2) | 2.6 (2.5-4.0) | .0062 | |
| Creatinine level, μM (range) | 88 (51-1759) | 88 (51-1025) | 140 (84-1759) | .013 | |
| Hemoglobulin level, g/dL (range) | 107 (52-192) | 107 (52-192) | 106 (82-137) | .84 | |
| Albumin level, g/L (range) | 39 (20-55) | 39 (20-55) | 35 (22-46) | .48 | |
| Time to ASCT, mo (range) | 9.0 (2.5-148.9) | 8.8 (2.5-148.9) | 10.1 (5.4-63.9) | .75 | |
| Chromosome abnormalities | |||||
| t(4:14), no. (%) | 12 (11.4) | 11 (11.6) | 1 (10.0) | .99 | |
| t(11:14), no. (%) | 15 (14.2) | 14 (14.7) | 1 (10.0) | .99 | |
| del(13q) (n = 93), no. (%) | 37 (39.8) | 31 (36.9) | 6 (66.7) | .15 | |
| Lytic lesions (n = 92), no. (%) | .14 | ||||
| 0 | 32 (34.8) | 31 (37.8) | 1 (10) | - | |
| 1-3 | 27 (29.3) | 24 (29.3) | 3 (30) | - | |
| More than 3 | 33 (35.8) | 27 (32.9) | 6 (60) | - | |
| Isotype (n = 101), no. (%) | .86 | ||||
| IgA | 25 (24.5) | 23 (25.0) | 2 (20.0) | - | |
| IgG | 56 (54.9) | 50 (54.4) | 6 (60.0) | - | |
| IgD | 3 (2.9) | 2 (2.0) | 1 (10.0) | - | |
| Light chains | 18 (17.7) | 17 (18.5) | 1 (10.0) | - | |
. | . | p53 deletion . | . | . | |
|---|---|---|---|---|---|
| Characteristics . | Total, n = 105 . | Absent, n = 95 . | Present, n = 10 . | P . | |
| Sex, female/male | 42/62 | 40/54 | 2/8 | .17 | |
| Age, y (range) | 53 (31-71) | 54 (31-69) | 51 (40-71) | .84 | |
| β2-microglobulin level, mM (range) | 218.5 (118-4910) | 219 (118-4910) | 315 (201-430) | .67 | |
| CRP level, mg/L (range) | 3.5 (2.0-122.0) | 3.5 (2.5-122.0) | 2.0 (2.0-2.0) | .092 | |
| Calcium level, mM (range) | 2.4 (1.6-4.2) | 2.4 (1.6-4.2) | 2.6 (2.5-4.0) | .0062 | |
| Creatinine level, μM (range) | 88 (51-1759) | 88 (51-1025) | 140 (84-1759) | .013 | |
| Hemoglobulin level, g/dL (range) | 107 (52-192) | 107 (52-192) | 106 (82-137) | .84 | |
| Albumin level, g/L (range) | 39 (20-55) | 39 (20-55) | 35 (22-46) | .48 | |
| Time to ASCT, mo (range) | 9.0 (2.5-148.9) | 8.8 (2.5-148.9) | 10.1 (5.4-63.9) | .75 | |
| Chromosome abnormalities | |||||
| t(4:14), no. (%) | 12 (11.4) | 11 (11.6) | 1 (10.0) | .99 | |
| t(11:14), no. (%) | 15 (14.2) | 14 (14.7) | 1 (10.0) | .99 | |
| del(13q) (n = 93), no. (%) | 37 (39.8) | 31 (36.9) | 6 (66.7) | .15 | |
| Lytic lesions (n = 92), no. (%) | .14 | ||||
| 0 | 32 (34.8) | 31 (37.8) | 1 (10) | - | |
| 1-3 | 27 (29.3) | 24 (29.3) | 3 (30) | - | |
| More than 3 | 33 (35.8) | 27 (32.9) | 6 (60) | - | |
| Isotype (n = 101), no. (%) | .86 | ||||
| IgA | 25 (24.5) | 23 (25.0) | 2 (20.0) | - | |
| IgG | 56 (54.9) | 50 (54.4) | 6 (60.0) | - | |
| IgD | 3 (2.9) | 2 (2.0) | 1 (10.0) | - | |
| Light chains | 18 (17.7) | 17 (18.5) | 1 (10.0) | - | |
- indicates not applicable (P values presented are from overall test).