Table 1.

Patupilone's effect on survival and tumor growth in an MM xenograft mouse model




No.

White blood cell count, × 109/L

Hematocrit

Platelet count × 109/L

Absolute neutrophil count, × 109/L
Control   8   5.1   36.2   1080   2.7  
Patupilone, 2.5 mg/kg per wk, 4 doses   8   5.5   38.3   1023   3.8  
Patupilone, 4 mg/kg, 1 dose
 
8
 
6.3
 
37.4
 
1282
 
2.3
 



No.

White blood cell count, × 109/L

Hematocrit

Platelet count × 109/L

Absolute neutrophil count, × 109/L
Control   8   5.1   36.2   1080   2.7  
Patupilone, 2.5 mg/kg per wk, 4 doses   8   5.5   38.3   1023   3.8  
Patupilone, 4 mg/kg, 1 dose
 
8
 
6.3
 
37.4
 
1282
 
2.3
 

Blood counts were measured when mice were killed. No significant difference was observed between treated mice and controls.

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