Table 3. Effect of unfractionated... | American Society of Hematology

Table 3.

Effect of unfractionated heparin or fondaparinux on the binding of annexin V, PAC1 monoclonal antibody, and anti-CD62 monoclonal antibody to platelets in the presence of sera*from patients with HIT

	No. of experiments	Annexin V, mean ± SEM	PAC1, mean ± SEM	anti-CD62, mean ± SEM
Control	14	4.30 ± 1.74	0.82 ± 0.33	1.51 ± 0.58
Heparin
0.1 IU/mL	14	18.30 ± 3.64	3.44 ± 1.00	11.98 ± 2.24
0.3 IU/mL	14	35.85 ± 4.78	5.49 ± 1.19	14.50 ± 2.04
1.0 IU/mL	10	47.58 ± 4.30	4.76 ± 1.26	14.53 ± 1.90
100.0 IU/mL	14	2.64 ± 0.59	0.35 ± 0.07	0.53 ± 0.13
Fondaparinux
0.1 μg/mL	14	3.44 ± 0.66	0.61 ± 0.25	1.74 ± 0.64
0.3 μg/mL	14	3.24 ± 0.65	0.59 ± 0.24	1.76 ± 0.61
1.0 μg/mL	10	2.20 ± 0.48	0.24 ± 0.05	0.85 ± 0.21
3.0 μg/mL	10	2.01 ± 0.41	0.19 ± 0.04	0.78 ± 0.18
100.0 μg/mL	14	2.47 ± 0.44	0.24 ± 0.05	0.46 ± 0.11

	No. of experiments	Annexin V, mean ± SEM	PAC1, mean ± SEM	anti-CD62, mean ± SEM
Control	14	4.30 ± 1.74	0.82 ± 0.33	1.51 ± 0.58
Heparin
0.1 IU/mL	14	18.30 ± 3.64	3.44 ± 1.00	11.98 ± 2.24
0.3 IU/mL	14	35.85 ± 4.78	5.49 ± 1.19	14.50 ± 2.04
1.0 IU/mL	10	47.58 ± 4.30	4.76 ± 1.26	14.53 ± 1.90
100.0 IU/mL	14	2.64 ± 0.59	0.35 ± 0.07	0.53 ± 0.13
Fondaparinux
0.1 μg/mL	14	3.44 ± 0.66	0.61 ± 0.25	1.74 ± 0.64
0.3 μg/mL	14	3.24 ± 0.65	0.59 ± 0.24	1.76 ± 0.61
1.0 μg/mL	10	2.20 ± 0.48	0.24 ± 0.05	0.85 ± 0.21
3.0 μg/mL	10	2.01 ± 0.41	0.19 ± 0.04	0.78 ± 0.18
100.0 μg/mL	14	2.47 ± 0.44	0.24 ± 0.05	0.46 ± 0.11

Sera nos. 2, 4, 6, 10, 11, 14, 18, 19, 22, 31, 32, 33, 35, and 39.

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