Table 4.

Molecular dimensions of individual αIIbβ3 molecules in the presence of Ca2+ or DTT




Head


No. of images measured
Transverse length, nm*
Vertical length, nm*
Stalk separation, nm*
Ca2+     
Closed   96   11.6 ± 1.8  9.0 ± 1.5  —  
Open   93   11.9 ± 1.9§  8.7 ± 1.4  13.1 ± 2.8 
DTT     
Closed   110   12.4 ± 1.5  8.7 ± 1.2  —  
Open
 
123
 
13.4 ± 2.0§
 
9.2 ± 1.1
 
18.1 ± 3.9
 



Head


No. of images measured
Transverse length, nm*
Vertical length, nm*
Stalk separation, nm*
Ca2+     
Closed   96   11.6 ± 1.8  9.0 ± 1.5  —  
Open   93   11.9 ± 1.9§  8.7 ± 1.4  13.1 ± 2.8 
DTT     
Closed   110   12.4 ± 1.5  8.7 ± 1.2  —  
Open
 
123
 
13.4 ± 2.0§
 
9.2 ± 1.1
 
18.1 ± 3.9
 

— indicates unmeasurable parameters.

*

Data are given as mean ± 1 SD.

Ca2+/closed versus DTT/closed, P = .027974.

Ca2+/closed versus DTT/closed, P = .344849.

§

Ca2+/open versus DTT/open, P = 2.98 × 10−7.

Ca2+/open versus DTT/open, P = 0.033581.

Ca2+/open versus DTT/open, P = 4.85 × 10−23.

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