Gene expression of pulmonary neutrophils from rhAPC-or placebo-treated volunteers
. | . | Mean signal . | . | . | . | |
|---|---|---|---|---|---|---|
| Gene symbol . | Gene title . | APC . | Placebo . | Fold increase, APC relative to placebo . | Probeset ID . | |
| TLK1 | Tousled-like kinase 1 | 15.7 | 70.3 | 0.22 | 210379_s_at | |
| LRAP | Leukocyte-derived arginine aminopeptidase | 199.5 | 862.5 | 0.23 | 219759_at | |
| ARTS-1 | Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator | 43.9 | 138.6 | 0.32 | 214012_at | |
| ATP6V1A | ATPase, H+ transporting, lysosomal 70 kDa, V1 subunit A | 382.3 | 964.1 | 0.40 | 201971_s_at | |
| DNCLI1 | Dynein, cytoplasmic, light intermediate polypeptide 1 | 493.4 | 1088.5 | 0.45 | 217976_s_at | |
| HDGFRP3 | Likely ortholog of mouse hepatoma-derived growth factor, related protein 3 | 87.2 | 182.3 | 0.48 | 209526_s_at | |
| AHCYL1 | S-adenosylhomocysteine hydrolase-like 1 | 253.2 | 516.1 | 0.49 | 200848_at | |
| FLOT1 | Flotillin 1 | 756.4 | 1510.8 | 0.50 | 208748_s_at | |
| MAFF | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) | 352.1 | 656.0 | 0.54 | 205193_at | |
| FLJ21439 | Hypothetical protein FLJ21439 | 869.5 | 1614.0 | 0.54 | 203513_at | |
| SSFA2 | Sperm specific antigen 2 | 455.8 | 811.5 | 0.56 | 202506_at | |
| ZFX | Zinc finger protein, X-linked | 178.0 | 310.8 | 0.57 | 207920_x_at | |
| EIF2S3 | Eukaryotic translation initiation factor 2, subunit 3 gamma, 52 kDa | 490.1 | 853.0 | 0.58 | 205321_at | |
| ALOX5 | Arachidonate 5-lipoxygenase | 3467.4 | 6004.8 | 0.58 | 214366_s_at | |
| PRKAB1 | Protein kinase, AMP-activated, beta 1 noncatalytic subunit | 220.7 | 379.5 | 0.58 | 201834_at | |
| C19orf6 | Chromosome 19 open reading frame 6 | 247.7 | 425.8 | 0.58 | 212574_x_at | |
| TIPR | Homo sapiens TIPR mRNA for inositol 1,4,5-trisphosphate receptor type 2 | 272.6 | 448.8 | 0.61 | 202662_s_at | |
| KIAA0252 | KIAA0252 protein | 265.5 | 436.1 | 0.61 | 212301_at | |
| ICAM1 | Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 621.8 | 1007.6 | 0.62 | 215485_s_at | |
| RRM2B | Ribonucleotide reductase M2 B (TP53 inducible) | 199.9 | 320.9 | 0.62 | 208883_at | |
| FLJ14345 | Hypothetical protein FLJ14345 | 224.9 | 356.1 | 0.63 | 220760_x_at | |
| NFYC | Nuclear transcription factor Y, gamma | 706.7 | 1073.4 | 0.66 | 211251_x_at | |
| BRD1 | Bromodomain containing 1 | 339.4 | 506.8 | 0.67 | 215460_x_at | |
| EKI1 | Ethanolamine kinase | 147.7 | 217.9 | 0.68 | 222262_s_at | |
| CASP9 | Caspase 9, apoptosis-related cysteine protease | 829.9 | 1129.7 | 0.74 | 210775_x_at | |
| nexilin | Likely ortholog of rat F-actin binding protein nexilin | 187.8 | 254.1 | 0.74 | 212847_at | |
| ZNF434 | Zinc finger protein 434 | 498.9 | 667.0 | 0.75 | 218937_at | |
| FLJ10948 | Hypothetical protein FLJ10948 | 303.3 | 244.2 | 1.24 | 218552_at | |
| MGC11256 | Hypothetical protein MGC11256 | 828.4 | 581.7 | 1.42 | 218358_at | |
| SPEC1 | Small protein effector 1 of Cdc42 | 1623.4 | 1121.4 | 1.45 | 218157_x_at | |
| RPL38 | Ribosomal protein L38 | 1164.4 | 733.7 | 1.59 | 202028_s_at | |
| RPS20 | Ribosomal protein S20 | 213.4 | 116.4 | 1.83 | 216246_at | |
| ZPBP | Zona pellucida binding protein | 198.1 | 84.6 | 2.34 | 207021_at | |
. | . | Mean signal . | . | . | . | |
|---|---|---|---|---|---|---|
| Gene symbol . | Gene title . | APC . | Placebo . | Fold increase, APC relative to placebo . | Probeset ID . | |
| TLK1 | Tousled-like kinase 1 | 15.7 | 70.3 | 0.22 | 210379_s_at | |
| LRAP | Leukocyte-derived arginine aminopeptidase | 199.5 | 862.5 | 0.23 | 219759_at | |
| ARTS-1 | Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator | 43.9 | 138.6 | 0.32 | 214012_at | |
| ATP6V1A | ATPase, H+ transporting, lysosomal 70 kDa, V1 subunit A | 382.3 | 964.1 | 0.40 | 201971_s_at | |
| DNCLI1 | Dynein, cytoplasmic, light intermediate polypeptide 1 | 493.4 | 1088.5 | 0.45 | 217976_s_at | |
| HDGFRP3 | Likely ortholog of mouse hepatoma-derived growth factor, related protein 3 | 87.2 | 182.3 | 0.48 | 209526_s_at | |
| AHCYL1 | S-adenosylhomocysteine hydrolase-like 1 | 253.2 | 516.1 | 0.49 | 200848_at | |
| FLOT1 | Flotillin 1 | 756.4 | 1510.8 | 0.50 | 208748_s_at | |
| MAFF | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) | 352.1 | 656.0 | 0.54 | 205193_at | |
| FLJ21439 | Hypothetical protein FLJ21439 | 869.5 | 1614.0 | 0.54 | 203513_at | |
| SSFA2 | Sperm specific antigen 2 | 455.8 | 811.5 | 0.56 | 202506_at | |
| ZFX | Zinc finger protein, X-linked | 178.0 | 310.8 | 0.57 | 207920_x_at | |
| EIF2S3 | Eukaryotic translation initiation factor 2, subunit 3 gamma, 52 kDa | 490.1 | 853.0 | 0.58 | 205321_at | |
| ALOX5 | Arachidonate 5-lipoxygenase | 3467.4 | 6004.8 | 0.58 | 214366_s_at | |
| PRKAB1 | Protein kinase, AMP-activated, beta 1 noncatalytic subunit | 220.7 | 379.5 | 0.58 | 201834_at | |
| C19orf6 | Chromosome 19 open reading frame 6 | 247.7 | 425.8 | 0.58 | 212574_x_at | |
| TIPR | Homo sapiens TIPR mRNA for inositol 1,4,5-trisphosphate receptor type 2 | 272.6 | 448.8 | 0.61 | 202662_s_at | |
| KIAA0252 | KIAA0252 protein | 265.5 | 436.1 | 0.61 | 212301_at | |
| ICAM1 | Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 621.8 | 1007.6 | 0.62 | 215485_s_at | |
| RRM2B | Ribonucleotide reductase M2 B (TP53 inducible) | 199.9 | 320.9 | 0.62 | 208883_at | |
| FLJ14345 | Hypothetical protein FLJ14345 | 224.9 | 356.1 | 0.63 | 220760_x_at | |
| NFYC | Nuclear transcription factor Y, gamma | 706.7 | 1073.4 | 0.66 | 211251_x_at | |
| BRD1 | Bromodomain containing 1 | 339.4 | 506.8 | 0.67 | 215460_x_at | |
| EKI1 | Ethanolamine kinase | 147.7 | 217.9 | 0.68 | 222262_s_at | |
| CASP9 | Caspase 9, apoptosis-related cysteine protease | 829.9 | 1129.7 | 0.74 | 210775_x_at | |
| nexilin | Likely ortholog of rat F-actin binding protein nexilin | 187.8 | 254.1 | 0.74 | 212847_at | |
| ZNF434 | Zinc finger protein 434 | 498.9 | 667.0 | 0.75 | 218937_at | |
| FLJ10948 | Hypothetical protein FLJ10948 | 303.3 | 244.2 | 1.24 | 218552_at | |
| MGC11256 | Hypothetical protein MGC11256 | 828.4 | 581.7 | 1.42 | 218358_at | |
| SPEC1 | Small protein effector 1 of Cdc42 | 1623.4 | 1121.4 | 1.45 | 218157_x_at | |
| RPL38 | Ribosomal protein L38 | 1164.4 | 733.7 | 1.59 | 202028_s_at | |
| RPS20 | Ribosomal protein S20 | 213.4 | 116.4 | 1.83 | 216246_at | |
| ZPBP | Zona pellucida binding protein | 198.1 | 84.6 | 2.34 | 207021_at | |
All genes shown are transcripts with a parametric P < .001.