Prognostic factors for overall and progression-free survival: multivariate model
. | . | Overall survival . | . | Progression-free survival . | . | ||
|---|---|---|---|---|---|---|---|
| Factors . | n/N(%) . | Hazard ratio (95% CI) . | P . | Hazard ratio (95% CI) . | P . | ||
| CHF | 19/73 (26) | 4.42 (2.23-8.74) | < .001 | 3.71 (1.98-6.95) | < .001 | ||
| Serum B2M level of at least 3.5 mg/L | 32/73 (44) | 2.80 (1.47-5.35) | .002 | 1.92 (1.08-3.42) | .026 | ||
. | . | Overall survival . | . | Progression-free survival . | . | ||
|---|---|---|---|---|---|---|---|
| Factors . | n/N(%) . | Hazard ratio (95% CI) . | P . | Hazard ratio (95% CI) . | P . | ||
| CHF | 19/73 (26) | 4.42 (2.23-8.74) | < .001 | 3.71 (1.98-6.95) | < .001 | ||
| Serum B2M level of at least 3.5 mg/L | 32/73 (44) | 2.80 (1.47-5.35) | .002 | 1.92 (1.08-3.42) | .026 | ||
The estimates of relative risk reported are simultaneously adjusted for B2M level of at least 3.5 mg/L and CHF.
Prognostic factors considered but not significant after adjusting for CHF and B2M level of at least 3.5 mg/L are age of 65 years or older, sex, performance status greater than 1, serum creatinine level at least 176.8 μM (2.0 mg/dL), serum albumin level less than 35 g/L (3.5 g/dL), serum alkaline phosphatase level greater than upper limit normal, and number of organ systems involved (> 2).