Major treatment-related toxicities of at least grade 3 by NCI Common Toxicity Criteria
. | Grade 3 . | Grade 4 . | Grade 5 . |
|---|---|---|---|
| Induction, n = 86 | |||
| Adverse event | |||
| Cardiovascular/fluid overload | 14 | 6 | 4 |
| Hematologic | 9 | 1 | 0 |
| Gastrointestinal | 7 | 2 | 0 |
| Renal | 5 | 2 | 0 |
| Infection | 5 | 1 | 0 |
| Total no. of patients | 29 | 11 | 4 |
| % | 34 | 12 | 5 |
| Maintenance, n = 49 | |||
| Adverse Event | |||
| Neurologic | 12 | 0 | 0 |
| Renal | 9 | 1 | 0 |
| Hematologic | 6 | 2 | 0 |
| Infection | 7 | 0 | 1 |
| Cardiovascular | 6 | 1 | 1 |
| Gastrointestinal | 5 | 2 | 0 |
| Flulike symptoms | 6 | 1 | 0 |
| Total no. of patients | 25 | 6 | 2 |
| % | 51 | 12 | 4 |
. | Grade 3 . | Grade 4 . | Grade 5 . |
|---|---|---|---|
| Induction, n = 86 | |||
| Adverse event | |||
| Cardiovascular/fluid overload | 14 | 6 | 4 |
| Hematologic | 9 | 1 | 0 |
| Gastrointestinal | 7 | 2 | 0 |
| Renal | 5 | 2 | 0 |
| Infection | 5 | 1 | 0 |
| Total no. of patients | 29 | 11 | 4 |
| % | 34 | 12 | 5 |
| Maintenance, n = 49 | |||
| Adverse Event | |||
| Neurologic | 12 | 0 | 0 |
| Renal | 9 | 1 | 0 |
| Hematologic | 6 | 2 | 0 |
| Infection | 7 | 0 | 1 |
| Cardiovascular | 6 | 1 | 1 |
| Gastrointestinal | 5 | 2 | 0 |
| Flulike symptoms | 6 | 1 | 0 |
| Total no. of patients | 25 | 6 | 2 |
| % | 51 | 12 | 4 |