Table 4.

Incidence of grades 2 to 4 nonhematologic toxicities during remission induction therapy with intensive chemotherapy and imatinib


Adverse event

Grade 2, no. (%)

Grade 3, no. (%)

Grade 4, no. (%)
Sepsis   0   3 (13)   0  
Other febrile neutropenia   1 (4)   6 (26)   0  
Symptomatic CMV infection   0   2 (8)   0  
Lung hemorrhage   1 (4)   0   1 (4)  
Diarrhea   1 (4)   1 (4)   0  
Ileus   1 (4)   2 (8)   0  
Nausea   1 (4)   4 (17)   0  
GPT   4 (17)   3 (13)   0  
Jaundice   1 (4)   0   0  
Pancreatitis   0   1 (4)   0  
Hyperglycemia   2 (8)   1 (4)   0  
Hypophosphatemia   1 (4)   0   0  
Hypokalemia   0   1 (4)   0  
Fluid retention   1 (4)   0   0  
Depression   3 (13)   0   0  
Muscle weakness
 
0
 
1 (4)
 
0
 

Adverse event

Grade 2, no. (%)

Grade 3, no. (%)

Grade 4, no. (%)
Sepsis   0   3 (13)   0  
Other febrile neutropenia   1 (4)   6 (26)   0  
Symptomatic CMV infection   0   2 (8)   0  
Lung hemorrhage   1 (4)   0   1 (4)  
Diarrhea   1 (4)   1 (4)   0  
Ileus   1 (4)   2 (8)   0  
Nausea   1 (4)   4 (17)   0  
GPT   4 (17)   3 (13)   0  
Jaundice   1 (4)   0   0  
Pancreatitis   0   1 (4)   0  
Hyperglycemia   2 (8)   1 (4)   0  
Hypophosphatemia   1 (4)   0   0  
Hypokalemia   0   1 (4)   0  
Fluid retention   1 (4)   0   0  
Depression   3 (13)   0   0  
Muscle weakness
 
0
 
1 (4)
 
0
 

CMV indicates cytomegalovirus.

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