Table 1.

Treatment schedule for BCR-ABL-positive ALL in the JALSG ALL202 study


Drug

Dose

Route

Days
Remission induction    
    CPM   1200 mg/m2*  3 h IV   1  
    DNR   60 mg/m2  1 h IV   1-3  
    VCR   1.3 mg/m2  IV   1, 8, 15, 22  
    PSL   60 mg/m2  PO   1-21§ 
    Imatinib   600 mg/d   PO   8-63  
    MTX, AraC, Dex   15, 40, 4 mg/d   IT   29  
Consolidation 1 (CI)    -  
    MTX   1 g/m2  24 h IV   1  
    AraC   2 g/m2  3 h IV   2, 3 (12 hourly)  
    MTX, AraC, Dex   15, 40, 4 mg/d   IT   1  
Consolidation 2 (C2)    
    Imatinib   600 mg/d   PO   1-28  
    MTX, AraC, Dex   15, 40, 4 mg/d   IT   1  
Maintenance    
    VCR   1.3 mg/m2  IV   1  
    PSL   60 mg/m2  PO   1-5  
    Imatinib
 
600 mg/d
 
PO
 
1-28
 

Drug

Dose

Route

Days
Remission induction    
    CPM   1200 mg/m2*  3 h IV   1  
    DNR   60 mg/m2  1 h IV   1-3  
    VCR   1.3 mg/m2  IV   1, 8, 15, 22  
    PSL   60 mg/m2  PO   1-21§ 
    Imatinib   600 mg/d   PO   8-63  
    MTX, AraC, Dex   15, 40, 4 mg/d   IT   29  
Consolidation 1 (CI)    -  
    MTX   1 g/m2  24 h IV   1  
    AraC   2 g/m2  3 h IV   2, 3 (12 hourly)  
    MTX, AraC, Dex   15, 40, 4 mg/d   IT   1  
Consolidation 2 (C2)    
    Imatinib   600 mg/d   PO   1-28  
    MTX, AraC, Dex   15, 40, 4 mg/d   IT   1  
Maintenance    
    VCR   1.3 mg/m2  IV   1  
    PSL   60 mg/m2  PO   1-5  
    Imatinib
 
600 mg/d
 
PO
 
1-28
 

C1 and C2 are alternatively repeated for 4 cycles. Maintenance is given every 4 weeks for 2 years from the date of CR.

CPM indicates cyclophosphamide; IV, intravenously; DNR, daunorubicin; VCR, vincristine; PSL, prednisolone; PO, per os; MTX, methotrexate; AraC, cytarabine; Dex, dexamethasone; and IT, intrathecally.

*

CPM 800 mg/m2 in case of patients aged 60 years or older.

DNR 30 mg/m2 in case of patients aged 60 years or older.

Max 2.0 mg in case of patients aged 60 years or older.

§

PSL for days 1 to 7 in case of patients aged 60 years or older.

AraC 1 g/m2 in case of patients aged 60 years or older.

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