Multivariable model of time to discontinuation of immunosuppressive treatment*
Variable . | Hazard ratio†(95% CI) . | P‡ . |
|---|---|---|
| Mobilized blood versus marrow | 0.5 (0.3-0.7) | < .0001 |
| Female donor for male recipient | 0.6 (0.4-0.8) | .0001 |
| No. of sites involved, per site | 0.8 (0.7-0.9) | .0002 |
| Serum bilirubin level more than 2 mg/dL at diagnosis | 0.6 (0.4-1.0) | .02 |
| No. of mismatched HLA loci, per locus | 0.8 (0.7-0.9) | .007 |
| Year of transplantation, per 5 y (1994-2000) | 0.7 (0.5-1.0) | .04 |
Variable . | Hazard ratio†(95% CI) . | P‡ . |
|---|---|---|
| Mobilized blood versus marrow | 0.5 (0.3-0.7) | < .0001 |
| Female donor for male recipient | 0.6 (0.4-0.8) | .0001 |
| No. of sites involved, per site | 0.8 (0.7-0.9) | .0002 |
| Serum bilirubin level more than 2 mg/dL at diagnosis | 0.6 (0.4-1.0) | .02 |
| No. of mismatched HLA loci, per locus | 0.8 (0.7-0.9) | .007 |
| Year of transplantation, per 5 y (1994-2000) | 0.7 (0.5-1.0) | .04 |
Ten patients were not included in the model because of missing data.
Hazard ratios less than 1.0 indicate a lower rate of discontinued treatment, resulting in a prolonged duration of treatment in the presence of the indicated risk factor as compared to its absence. In this model, death and recurrent malignancy were treated as competing risks. Follow-up was censored for patients who died or had recurrent malignancy before immunosuppressive treatment was discontinued.
Likelihood ratio test.