Profile of kinase inhibition for MLN518 and PD180970
. | MLN518 IC50, nM . | Pyrido[2,3-d]pyrimidine IC50, nM . |
|---|---|---|
| KIT | 170 | 50 |
| PDGFR | 200 | - |
| Flt3 | 220 | - |
| Abl | > 10 000 | 170 |
| Src | > 10 000 | 0.8 |
. | MLN518 IC50, nM . | Pyrido[2,3-d]pyrimidine IC50, nM . |
|---|---|---|
| KIT | 170 | 50 |
| PDGFR | 200 | - |
| Flt3 | 220 | - |
| Abl | > 10 000 | 170 |
| Src | > 10 000 | 0.8 |
indicates unknown. IC50 values represent inhibition of intracellular kinase phosphorylation by the respective inhibitors (except PD180970 inhibition of Src, which was reported as a kinase assay of the purified enzyme)